S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
Jean-Philippe Lambert,Gordana Ivosev,Amber L. Couzens,Brett Larsen,Mikko Taipale,Zhen-Yuan Lin,Quan Zhong,Susan Lindquist,Susan Lindquist,Marc Vidal,Ruedi Aebersold,Ruedi Aebersold,Tony Pawson,Tony Pawson,Ron Bonner,Stephen A. Tate,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: It is shown that AP-SWATH is a robust label-free approach to characterize changes in protein-protein interactions imparted by the HSP90 inhibitor NVP-AUY922 or melanoma-associated mutations in the human kinase CDK4 and proposed a scalable pipeline for systems biology studies.
Journal ArticleDOI
The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader
TL;DR: It is found that the hsp70 message is not translated at high temperatures when its leader sequence is deleted, and the specific feature responsible for the preferential translation of heat-shock messages must reside in the 5' untranslated leader.
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Ruth Scherz-Shouval,Sandro Santagata,Marc L. Mendillo,Lynette M. Sholl,Irit Ben-Aharon,Andrew H. Beck,Dora Dias-Santagata,Salomon M. Stemmer,Luke Whitesell,Martina Koeva,Susan Lindquist +10 more
TL;DR: In this article, the authors report that the transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of malignancy.
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
Nicolas Rohner,Daniel F. Jarosz,Johanna E. Kowalko,Masato Yoshizawa,William R. Jeffery,William R. Jeffery,Richard Borowsky,Susan Lindquist,Susan Lindquist,Clifford J. Tabin +9 more
TL;DR: In this article, heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus, resulting in reduced-eye phenotype even in the presence of full HSP90 activity.
Journal ArticleDOI
Prion switching in response to environmental stress.
TL;DR: The hypothesis that [PSI+] is a mechanism to increase survival in fluctuating environments and might function as a capacitor to promote evolvability is supported.