Susanna Akiki

TL;DR: Although mutations associated with preleukemic clones remained detectable during ongoing remission after chemotherapy, NPM1 mutations were detected in 69 of 70 patients at the time of relapse and provided a better marker of disease status.

TL;DR: A robust, reliable assay for sensitive JAK2-V617F detection is established, suitable for assessing response in clinical trials, predicting outcome and guiding management of patients undergoing allogeneic transplant.

TL;DR: The most important issues for a clinical diagnostic laboratory in choosing a technique, particularly for detection of the JAK2 V617F mutation at diagnosis are discussed, including how to detect a mutant allele burden as low as 1–3%.

TL;DR: Two suitability studies performed by 63 BCR-ABL1 testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 BCR–ABL 1 and three control genes.

TL;DR: To elucidate how chronic growth factor signaling alters the transcriptional network in AML, a system-wide multi-omics study of primary cells from patients suffering from AML with internal tandem duplications in the FLT3 transmembrane domain revealed cooperation between the MAP kinase (MAPK) inducible transcription factor AP-1 and RUNX1 as a major driver of a common,FLT3-ITD-specific gene expression and chromatin signature.