Susanne K. Kjaer

TL;DR: In this article, the authors used microcell-mediated chromosome transfer approach and expression microarray analysis to identify genes that were associated with neoplastic suppression in ovarian cancer cell lines, and they found significant associations with survival for a tSNP in caspase 5 (CASP5) [hazard ratio (HR) = 1.13 (95% CI: 1.00-1.27), P = 0.75-0.95), and two tSNPs in the retinoblastoma binding protein (RBBP8) gene [HR = 0

TL;DR: It is suggested that smoking is an important predictor of later heavy drinking among young women and that this relatively elevated risk is most pronounced among women with an early sexual debut.

TL;DR: It is unlikely that common variants in the MMR pathways examined have moderate effects on survival after diagnosis with ovarian cancer, and much larger studies would be needed to exclude common variants with small effects.

TL;DR: A two-pronged approach to identify candidate causal SNPs and assess underlying biological mechanisms at chromosome 9p22.2 identifies BNC2 as an ovarian cancer risk gene and proposes a likely mechanism of susceptibility to ovarian cancer.

TL;DR: The results suggest that high BMI and race may influence CA125 levels independent of tumor characteristics, and validation is needed in studies that use a single assay for CA125 measurement and have a diverse study population.