Molecular Modeling of the Extracellular Domain of the RET Receptor Tyrosine Kinase Reveals Multiple Cadherin-like Domains and a Calcium-binding Site
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TLDR
The models of the cadherin-like domains of human RET represent valuable tools with which to guide future site-directed mutagenesis studies aimed at identifying residues involved in ligand binding and receptor activation.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-09-21 and is currently open access. It has received 167 citations till now. The article focuses on the topics: Proto-Oncogene Proteins c-ret & Glial cell line-derived neurotrophic factor.read more
Citations
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The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.
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Involvement of Members of the Cadherin Superfamily in Cancer
Geert Berx,Frans Van Roy +1 more
TL;DR: The role of cadherins and cadherin-related proteins in human cancer is reviewed, including E-cadherin, the prototype of the large cadher in superfamily, which is renowned for its potent malignancy suppressing activity.
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Quinoline as a Privileged Scaffold in Cancer Drug Discovery
Solomon Vr,Hoyun Lee +1 more
TL;DR: In vitro and in vivo anticancer activities of quinoline and its analogs are focused on in the context of cancer drug development and refinement, and selective and specific activity against various cancer drug targets are reviewed.
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RET tyrosine kinase signaling in development and cancer.
TL;DR: The role and mechanisms of RET signaling in development and carcinogenesis are reviewed and a deeper understanding of the molecular signaling of normal versus abnormal RET activity in cancer will enable the development of potential new treatments for patients with sporadic and inherited thyroid cancer or MEN 2 syndrome.
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RET revisited: expanding the oncogenic portfolio
TL;DR: The complex roles of RET in homeostasis and survival of neural lineages and in tumour-associated inflammation might also suggest potential long-term pitfalls of broadly targeting RET.
References
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PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
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TreeView : an application to display phylogenetic trees on personal computers
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The Protein Data Bank: a computer-based archival file for macromolecular structures.
Frances C. Bernstein,Thomas F. Koetzle,Graheme J. B. Williams,Edgar F. Meyer,Michael D. Brice,John R. Rodgers,O. Kennard,Takehiko Shimanouchi,Mitsuo Tasumi +8 more
TL;DR: The Protein Data Bank is a computer-based archival file for macromolecular structures that stores in a uniform format atomic co-ordinates and partial bond connectivities, as derived from crystallographic studies.
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WHAT IF: A molecular modeling and drug design program
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