S
Sylvie van der Werf
Researcher at Pasteur Institute
Publications - 235
Citations - 17249
Sylvie van der Werf is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 48, co-authored 235 publications receiving 14083 citations. Previous affiliations of Sylvie van der Werf include Centre national de la recherche scientifique & World Health Organization.
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Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms
Estelle M.N. Laurent,Yorgos Sofianatos,Anastassia V. Komarova,Jean-Pascal Gimeno,Payman Samavarchi Tehrani,Dae-Kyum Kim,Hala Abdouni,Marie Duhamel,Patricia Cassonnet,Jennifer J. Knapp,Da Kuang,Aditya Chawla,Dayag Sheykhkarimli,Ashyad Rayhan,Roujia Li,Oxana Pogoutse,David E. Hill,Michael A. Calderwood,Pascal Falter-Braun,Patrick Aloy,Ulrich Stelzl,Marc Vidal,Anne-Claude Gingras,Georgios A. Pavlopoulos,Sylvie van der Werf,Isabelle Fournier,Frederick P. Roth,Michel Salzet,Caroline Demeret,Yves Jacob,Etienne Coyaud +30 more
TL;DR: This study provides an unprecedented comprehensive resource for understanding how SARS-CoV-2 proteins orchestrate host proteome remodeling and innate immune response evasion, which can inform development of targeted therapeutic strategies.
Journal ArticleDOI
Two-Component Spike Nanoparticle Vaccine Protects Macaques from SARS-CoV-2 Infection
Philip J. M. Brouwer,Mitch Brinkkemper,Pauline Maisonasse,Nathalie Dereuddre-Bosquet,Marloes Grobben,Mathieu Claireaux,Marlon de Gast,Romain Marlin,Virginie Chesnais,Ségolène Diry,Joel D. Allen,Yasunori Watanabe,Julia M. Giezen,Gius Kerster,Hannah L. Turner,Karlijn van der Straten,Cynthia A. van der Linden,Yoann Aldon,Thibaut Naninck,Ilja Bontjer,Judith A. Burger,Meliawati Poniman,Anna Z Mykytyn,Nisreen M.A. Okba,Edith E. Schermer,Mariëlle J. van Breemen,Rashmi Ravichandran,Tom G. Caniels,Jelle van Schooten,Nidhal Kahlaoui,Vanessa Contreras,Julien Lemaitre,Catherine Chapon,Raphael Ho Tsong Fang,Julien Villaudy,Kwinten Sliepen,Yme U. van der Velden,Bart L. Haagmans,Godelieve J. de Bree,Eric Ginhoux,Andrew B. Ward,Max Crispin,Neil P. King,Sylvie van der Werf,Marit J. van Gils,Roger Le Grand,Rogier W. Sanders +46 more
TL;DR: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques, resulting in strongly reduced viral infection and replication in upper and lower airways.
Journal ArticleDOI
Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes.
Ida Rosenkrands,Carina Vingsbo-Lundberg,Trine Junker Bundgaard,Thomas Lindenstrøm,Vincent Enouf,Vincent Enouf,Vincent Enouf,Sylvie van der Werf,Sylvie van der Werf,Sylvie van der Werf,Peter Andersen,Else Marie Agger +11 more
TL;DR: This study demonstrates that administration of trivalent influenza vaccine (TIV) with the cationic liposome adjuvant system CAF01 enhances the humoral immune response as measured by hemagglutinin inhibition titers and influenza-specific serum antibody titers, and promotes a strong Th1 response with augmented levels of IL-1β, IL-2, IFN-γ and TNF-α.
Journal ArticleDOI
Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo.
TL;DR: The results suggest that less strict type-specific interactions are involved for the polymerase complex of influenza A compared with influenza B or C viruses.
Journal ArticleDOI
Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules
Marie-Anne Rameix-Welti,Maria Leticia Zarantonelli,Dario Giorgini,Corinne Ruckly,Monica Marasescu,Sylvie van der Werf,Jean-Michel Alonso,Nadia Naffakh,Muhamed-Kheir Taha +8 more
TL;DR: Findings suggest that a direct interaction between the NA of IAV and the capsule of N. meningitidis enhances bacterial adhesion to cultured epithelial cells, most likely through cleavage of capsular sialic acid-containing polysaccharides.