S
Sylvie van der Werf
Researcher at Pasteur Institute
Publications - 235
Citations - 17249
Sylvie van der Werf is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 48, co-authored 235 publications receiving 14083 citations. Previous affiliations of Sylvie van der Werf include Centre national de la recherche scientifique & World Health Organization.
Papers
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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Philip J. M. Brouwer,Mitch Brinkkemper,Pauline Maisonnasse,Nathalie Dereuddre-Bosquet,Marloes Grobben,Mathieu Claireaux,Marlon de Gast,Romain Marlin,Virginie Chesnais,Ségolène Diry,Joel D. Allen,Yasunori Watanabe,Yasunori Watanabe,Julia M. Giezen,Gius Kerster,Hannah L. Turner,Karlijn van der Straten,Cynthia A. van der Linden,Yoann Aldon,Thibaut Naninck,Ilja Bontjer,Judith A. Burger,Meliawati Poniman,Anna Z Mykytyn,Nisreen M.A. Okba,Edith E. Schermer,Mariëlle J. van Breemen,Rashmi Ravichandran,Tom G. Caniels,Jelle van Schooten,Nidhal Kahlaoui,Vanessa Contreras,Julien Lemaitre,Catherine Chapon,Raphael Ho Tsong Fang,Julien Villaudy,Kwinten Sliepen,Yme U. van der Velden,Bart L. Haagmans,Godelieve J. de Bree,Eric Ginoux,Andrew B. Ward,Max Crispin,Neil P. King,Sylvie van der Werf,Marit J. van Gils,Roger Le Grand,Rogier W. Sanders +47 more
TL;DR: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques, resulting in strongly reduced viral infection and replication in upper and lower airways.
Journal ArticleDOI
High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort.
Sarah Tubiana,Charles Burdet,N. Houhou,Michael Thy,Pauline Manchon,François Blanquart,Charlotte Charpentier,Jeremie Guedj,Loubna Alavoine,Sylvie Behillil,Anne Leclercq,Jean-Christophe Lucet,Yazdan Yazdanpanah,Mikaël Attia,Caroline Demeret,Thierry Rose,Julia Bielicki,Patricia Bruijning-Verhagen,Herman Goossens,Diane Descamps,Sylvie van der Werf,Bruno Lina,Xavier Duval +22 more
Posted ContentDOI
Viral dynamic modeling of SARS-CoV-2 in non-human primates
Antonio Gonçalves,Pauline Maisonnasse,Flora Donati,Mélanie Albert,Sylvie Behillil,Vanessa Contreras,Thibaut Naninck,Romain Marlin,Caroline Solas,Andrés Pizzorno,Julien Lemaitre,Nidhal Kahlaoui,Olivier Terrier,Raphael Ho Tsong Fang,Vincent Enouf,Nathalie Dereuddre-Bosquet,Angela Brisbarre,Franck Touret,Catherine Chapon,Bruno Hoen,Bruno Lina,Manuel Rosa-Calatrava,Xavier de Lamballerie,Roger Le Grand,Sylvie van der Werf,Jeremie Guedj +25 more
TL;DR: A mathematical model is used to characterize in detail the viral dynamics in 31 cynomolgus macaques infected with 106 pfu of SARS-CoV-2 and identified that infected cells had a large daily viral production and a within-host reproductive basic number of 6 and 4 in nasopharyngeal and tracheal compartment, respectively.
Patent
Peptides containing an immunogenic site of the poliovirus, and DNA's containing nucleotide fragments encoding for these peptides
Marc Girard,Sylvie van der Werf +1 more
TL;DR: In this paper, a DNA fragment containing at most 315 pairs of nucleotides, characterized in that it codes for a peptide capable of being recognized by antibodies active both against particles "C" and "D" d a same poliovirus and against the VP-1 structural polypeptide of the capsid of this polievirus.
Posted ContentDOI
High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort
Sarah Tubiana,Charles Burdet,N. Houhou,Michael Thy,Pauline Manchon,François Blanquart,François Blanquart,Charlotte Charpentier,Jeremie Guedj,Loubna Alavoine,Sylvie Behillil,Sylvie Behillil,Anne Leclercq,Jean-Christophe Lucet,Yazdan Yazdanpanah,Mickael Attia,Caroline Demeret,Thierry Rose,Julia Bielicki,Julia Bielicki,Patricia Bruijning-Verhagen,Herman Goossens,Diane Descamps,Sylvie van der Werf,Sylvie van der Werf,Bruno Lina,Xavier Duval +26 more
TL;DR: The proportion of HCWs with confirmed or possible SARS-CoV-2 infection was high, and there were less occurrences of high-risk exposure with patients than with colleagues, but those were associated with an increased risk of infection.