T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system.
Takumi Nakamura,Kazuo Nakajima,Tetsuo Ohnishi,Takeo Yoshikawa,Moe Nakanishi,Toru Takumi,Takashi Tsuboi,Tadafumi Kato +7 more
TL;DR: The LAI calculated from the genotypes of F1 mice tended to be lower in disease-related genes, and correlated with the frequency of loss-of-function (LOF) alleles in humans, support the potential usefulness of the LAI as an index of preweaning lethality in genome-edited mice.
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Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia
Akihito Uezato,Daisuke Jitoku,Dai Shimazu,Naoki Yamamoto,Akeo Kurumaji,Yoshimi Iwayama,Tomoko Toyota,Takeo Yoshikawa,Vahram Haroutunian,Eduard-Mihai Bentea,J. Meller,Courtney R. Sullivan,James H. Meador-Woodruff,Robert E. McCullumsmith,Toru Nishikawa +14 more
TL;DR: Findings indicate that SLC35B2 might be differentially involved in the pathophysiology of BD and SCZ by influencing the sulfation process and/or glutamate system in the central nervous system.
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Oral L-histidine supplementation improves working memory through the activation of brain histamine system in male mice
TL;DR: In this article , the importance of histidine intake in the histaminergic nervous system and working memory in stressful conditions was elucidated, and it was shown that histidine supplementation alleviated impaired memory function induced by water-floor (WF) stress.
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Histamine H3 receptor expressed on pancreatic β-cells downregulate its insulin secretion and proliferation
TL;DR: H 3 R in pancreatic β cells has negative impact on insulin secretion and their proliferation and Morphometric analysis revealed the increased number and size of islets in cKO pancreas, indicating that proliferation of β cells was enhanced by H 3 R deletion.
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From the EGR gene family to common pathways in schizophrenia: single genes versus convergent pathways
Kazuo Yamada,Takeo Yoshikawa +1 more
TL;DR: The strategy for finding putative molecular pathways leading to schizophrenia is described, and highly plausible candidate genes, such as BDNF, AKT1 and DISC1, have been identified through multipronged strategies.