T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
Naoko Morimura,Hiroki Yasuda,Kazuhiko Yamaguchi,Kei-ichi Katayama,Minoru Hatayama,Minoru Hatayama,Naoko H. Tomioka,Maya Odagawa,Akiko Kamiya,Yoshimi Iwayama,Motoko Maekawa,Kazuhiko Nakamura,Hideo Matsuzaki,Masatsugu Tsujii,Kazuyuki Yamada,Takeo Yoshikawa,Jun Aruga,Jun Aruga +17 more
TL;DR: It is shown that Lrfn2 knockout mice exhibit autism-like behavioural abnormalities, including social withdrawal, decreased vocal communications, increased stereotyped activities and prepulse inhibition deficits, together with enhanced learning and memory.
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Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees
Shinsuke Washizuka,Kazuya Iwamoto,An-a Kazuno,Chihiro Kakiuchi,Kanako Mori,Mizue Kametani,Kazuo Yamada,Hiroshi Kunugi,Osamu Tajima,Tsuyoshi Akiyama,Shinichiro Nanko,Takeo Yoshikawa,Tadafumi Kato +12 more
TL;DR: Findings indicate that the polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder by affecting promoter activity.
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Clinical Features of Schizophrenia With Enhanced Carbonyl Stress
Mitsuhiro Miyashita,Mitsuhiro Miyashita,Mitsuhiro Miyashita,Makoto Arai,Akiko Kobori,Tomoe Ichikawa,Kazuya Toriumi,Kazuhiro Niizato,Kenichi Oshima,Yuji Okazaki,Takeo Yoshikawa,Naoji Amano,Toshio Miyata,Masanari Itokawa +13 more
TL;DR: The results support the idea that treatment regimes reducing carbonyl stress, such as supplementation of pyridoxamine, could provide novel therapeutic benefits for this subgroup of patients, and psychopathological symptoms showed a tendency towards negative association with serum vitamin B6 levels.
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A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.
TL;DR: The physical position and possible function suggest that IMP.18p is an important candidate gene for bipolar disorder.
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Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia
Hiromitsu Shimizu,Yoshimi Iwayama,Kazuo Yamada,Tomoko Toyota,Yoshio Minabe,Kauhiko Nakamura,Mizuho Nakajima,Eiji Hattori,Norio Mori,Noriko Osumi,Takeo Yoshikawa +10 more
TL;DR: The genetic contribution of MAP6 to schizophrenia is examined in a case -control study using dense single nucleotide polymorphism (SNP) markers and associations between the 3' genomic interval of the gene and schizophrenia are detected.