T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.
Yoshimi Iwayama,Eiji Hattori,Motoko Maekawa,Kazuo Yamada,Tomoko Toyota,Tetsuo Ohnishi,Yasuhide Iwata,Kenji J. Tsuchiya,Genichi Sugihara,Mitsuru Kikuchi,Kenji Hashimoto,Masaomi Iyo,Toshiya Inada,Hiroshi Kunugi,Norio Ozaki,Nakao Iwata,Shinichiro Nanko,Kazuya Iwamoto,Yuji Okazaki,Tadafumi Kato,Takeo Yoshikawa +20 more
TL;DR: Three single nucleotide polymorphisms from FABP7 showed nominal association with bipolar disorder, and haplotypes of the same gene showed empirical associations with bipolar Disorder even after correction of multiple testing.
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Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder.
Ayyappan Anitha,Kazuhiko Nakamura,Kazuo Yamada,Yoshimi Iwayama,Tomoko Toyota,Nori Takei,Yasuhide Iwata,Katsuaki Suzuki,Yoshimoto Sekine,Hideo Matsuzaki,Masayoshi Kawai,Ko Miyoshi,Taiichi Katayama,Shinsuke Matsuzaki,Kousuke Baba,Akiko Honda,Tsuyoshi Hattori,Shoko Shimizu,Natsuko Kumamoto,Masaya Tohyama,Takeo Yoshikawa,Norio Mori +21 more
TL;DR: Elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder, by gene expression analysis and genetic association study.
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Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation
Akiko Matsuura,Tamaki Ishima,Yuko Fujita,Yoshimi Iwayama,Shunsuke Hasegawa,Ryouka Kawahara-Miki,Motoko Maekawa,Manabu Toyoshima,Yusuke Ushida,Hiroyuki Suganuma,Satoshi Kida,Takeo Yoshikawa,Masaomi Iyo,Kenji Hashimoto +13 more
TL;DR: It is demonstrated that dietary intake of glucoraphanin (GF), the precursor of a natural antioxidant sulforaphane, during juvenile and adolescent stages prevented cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial prefrontal cortex of adult offspring after MIA.
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Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population.
Neetha N Vijayan,Yoshimi Iwayama,Linda V. Koshy,Chandrasekhar Natarajan,Chandrashekharan M Nair,Priya M Allencherry,Takeo Yoshikawa,Moinak Banerjee +7 more
TL;DR: A strong role is suggested for SLC6A4 in schizophrenia, possibly with a specific behavioral endophenotype in a South Indian population, comprising 586 individuals.
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Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects
Shabeesh Balan,Yoshimi Iwayama,Motoko Maekawa,Tomoko Toyota,Tetsuo Ohnishi,Manabu Toyoshima,Chie Shimamoto,Kayoko Esaki,Kazuo Yamada,Yasuhide Iwata,Katsuaki Suzuki,Masayuki Ide,Motonori Ota,Satoshi Fukuchi,Masatsugu Tsujii,Masatsugu Tsujii,Norio Mori,Yoichi Shinkai,Takeo Yoshikawa +18 more
TL;DR: It is suggested that rare functional variants in these genes that regulate H3K9 methylation may be associated with ASD and the elevated expression of EHMT2 in the peripheral blood cells may support the notion of a restrictive chromatin state in ASD, similar to schizophrenia.