T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder.
Tadafumi Kato,Akiko Hayashi-Takagi,Akiko Hayashi-Takagi,Tomoko Toyota,Takeo Yoshikawa,Kazuya Iwamoto,Kazuya Iwamoto +6 more
TL;DR: This study was the first to suggest a possible role of gene expression analysis of ANK3, RASGRP1 and POLG1 in the LCLs as potential biomarkers of BD.
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Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor α6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression
TL;DR: Analysis of transcriptional activity and analyses of tandem Alu repeats confirmed their role as transcriptional repressors regardless of their orientation and copy number, which may explain the limited expression of the CHRNA6 gene in the brain.
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Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder.
Takaoki Kasahara,Mizuho Ishiwata,Chihiro Kakiuchi,Satoshi Fuke,Nakao Iwata,Norio Ozaki,Hiroshi Kunugi,Yoshio Minabe,Kazuhiko Nakamura,Yasuhide Iwata,Kumiko Fujii,Kumiko Fujii,Shigenobu Kanba,Hiroshi Ujike,Ichiro Kusumi,Muneko Kataoka,Nana Matoba,Atsushi Takata,Kazuya Iwamoto,Takeo Yoshikawa,Tadafumi Kato +20 more
TL;DR: This study examined the impacts of amino acid substitution variants in the POLG1 found in bipolar disorder in three different modalities of assessment: in silico predictions, in vitro biochemical assays, and clinical evaluation, and tested whether deleterious variants inPOLG1 contributed to the genetics of bipolar disorder.
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Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
TL;DR: The criteria predict that the common disease/common variant hypothesis is unlikely to fit schizophrenia and that nuclear susceptibility genes of moderate effects for schizophrenia, if present, are limited to ‘rare variants’, ‘very common variants‘, or variants with exceptionally high mutation rates.
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Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
Yukika Nishimura,Ryu Takizawa,Shinsuke Koike,Akihide Kinoshita,Yoshihiro Satomura,Shingo Kawasaki,Hidenori Yamasue,Mamoru Tochigi,Chihiro Kakiuchi,Tsukasa Sasaki,Yoshimi Iwayama,Kazuo Yamada,Takeo Yoshikawa,Kiyoto Kasai +13 more
TL;DR: In vivo human evidence of a significant influence of EGR3 polymorphisms on prefrontal hemodynamic activation level in healthy adults and in patients with SZ is provided, illustrating the usefulness of NIRS in imaging genetics investigations on psychiatric disorders.