T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse.
TL;DR: The effects of Fabp7, and another Fabp, Fabp5, on postnatal neurogenesis are demonstrated and differential roles for proliferation and survival of the NSCs/NPCs during postnatal DG neuroGenesis are suggested.
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Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.
Tadao Arinami,Tsuyuka Ohtsuki,Hiroki Ishiguro,Hiroshi Ujike,Yuji Tanaka,Yukitaka Morita,Mari Mineta,Masashi Takeichi,Shigeto Yamada,Akira Imamura,Koichi Ohara,Haruo Shibuya,Kenshiro Ohara,Yasuo Suzuki,Tatsuyuki Muratake,Naoshi Kaneko,Toshiyuki Someya,Toshiya Inada,Takeo Yoshikawa,Tomoko Toyota,Kazuo Yamada,Takuya Kojima,Sakae Takahashi,Ohmori Osamu,Takahiro Shinkai,Michiko Nakamura,Hiroshi Fukuzako,Tomo Hashiguchi,Tomo Hashiguchi,Shin ich Niwa,Takuya Ueno,Hirokazu Tachikawa,Takafumi Hori,Takashi Asada,Shinichiro Nanko,Hiroshi Kunugi,Ryota Hashimoto,Norio Ozaki,Nakao Iwata,Mutsuo Harano,Heii Arai,Tohru Ohnuma,Ichiro Kusumi,Tsukasa Koyama,Hiroshi Yoneda,Yasuyuki Fukumaki,Hiroki Shibata,Sunao Kaneko,Hisashi Higuchi,Norio Yasui-Furukori,Yohtaro Numachi,Masanari Itokawa,Yujitno Okazaki +52 more
TL;DR: Results of the present study, which, to the authors' knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASP's of European descent, indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.
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A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia.
Masanari Itokawa,Kazuo Yamada,Kiyoshi Yoshitsugu,Tomoko Toyota,Toshiro Suga,Hisako Ohba,Akiko Watanabe,Eiji Hattori,Hiromitsu Shimizu,Tetsuo Kumakura,Mitsuru Ebihara,Joanne M.A. Meerabux,Michio Toru,Takeo Yoshikawa +13 more
TL;DR: Results illustrate a genotype-phenotype correlation in schizophrenia and suggest that the longer (GT)(n) stretch may act as a risk-conferring factor that worsens chronic outcome by reducing GRIN2A levels in the brain.
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A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.
Mika Aoki-Suzuki,Mika Aoki-Suzuki,Kazuo Yamada,Joanne M.A. Meerabux,Yoshimi Iwayama-Shigeno,Hisako Ohba,Kazuya Iwamoto,Hitomi Takao,Tomoko Toyota,Yumiko Suto,Noriaki Nakatani,Brian Dean,Sachiko Nishimura,Kenjiro Seki,Tadafumi Kato,Shigeyoshi Itohara,Toru Nishikawa,Takeo Yoshikawa +17 more
TL;DR: Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains.
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Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.
Noriko Yoshimi,Takashi Futamura,Sarah E. Bergen,Yoshimi Iwayama,Tamaki Ishima,Carl M. Sellgren,C J Ekman,Joel Jakobsson,Erik Pålsson,Keiji Kakumoto,Yuta Ohgi,Takeo Yoshikawa,Mikael Landén,Mikael Landén,Kenji Hashimoto +14 more
TL;DR: Findings suggest that abnormality in the metabolism of isocitrate by IDH3A in the mitochondria plays a key role in the pathogenesis of BD, supporting the mitochondrial dysfunction hypothesis of BD.