T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Evaluation of Pax6 Mutant Rat as a Model for Autism
Toshiko Umeda,Noriko Takashima,Noriko Takashima,Ryoko Nakagawa,Motoko Maekawa,Shiro Ikegami,Shiro Ikegami,Takeo Yoshikawa,Kazuto Kobayashi,Kazuo Okanoya,Kaoru Inokuchi,Kaoru Inokuchi,Noriko Osumi +12 more
TL;DR: In this article, the authors examined behaviors of rSey2+ rats and revealed that they exhibited abnormality in social interaction (more aggression and withdrawal) in addition to impairment in rearing activity and in fear-conditioned memory.
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Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes
Motoko Maekawa,Akiko Watanabe,Yoshimi Iwayama,T Kimura,Kei Hamazaki,Shabeesh Balan,Hisako Ohba,Yasuko Hisano,Yayoi Nozaki,Tetsuo Ohnishi,Manabu Toyoshima,Chie Shimamoto,Kazuya Iwamoto,Miki Bundo,Noriko Osumi,E Takahashi,Akihiko Takashima,Akihiko Takashima,Takeo Yoshikawa +18 more
TL;DR: It is shown that gestational and early postnatal dietary deprivation of two PUFAs—arachidonic acid (AA) and docosahexaenoic acid (DHA)—elicited schizophrenia-like phenotypes in mouse offspring at adulthood, suggesting that PUFA deficiency during the early neurodevelopmental period in mice could model the prodromal state of schizophrenia through changes in the epigenetic regulation of nuclear receptor genes.
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Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.
Takeshi Otowa,Yukiko Kawamura,Nao Nishida,Nagisa Sugaya,Asako Koike,Eiji Yoshida,Ken Inoue,Shin Yasuda,Yukika Nishimura,Yukika Nishimura,Xiaoxi Liu,Yoshiaki Konishi,Fumichika Nishimura,Takafumi Shimada,Hitoshi Kuwabara,Mamoru Tochigi,Chihiro Kakiuchi,Tadashi Umekage,Taku Miyagawa,Akinori Miyashita,Eiji Shimizu,J Akiyoshi,Toshiyuki Someya,Tadafumi Kato,Takeo Yoshikawa,Ryozo Kuwano,Kiyoto Kasai,Nobumasa Kato,Hisanobu Kaiya,Katsushi Tokunaga,Yuji Okazaki,Hisashi Tanii,Tsukasa Sasaki +32 more
TL;DR: The findings suggest that large sets of common variants of small effects collectively account for risk of PD.
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Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.
Tadafumi Kato,Yoshimi Iwayama,Chihiro Kakiuchi,Kazuya Iwamoto,Kazuo Yamada,Yoshio Minabe,Kazuhiko Nakamura,Norio Mori,Kumiko Fujii,Shinichiro Nanko,Takeo Yoshikawa +10 more
TL;DR: The results suggest that SNPs in the upstream region of LIM may confer the genetic risk for bipolar disorder.
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Protocadherin α(PCDHA ) as a novel susceptibility gene for autism
Ayyappan Anitha,Ismail Thanseem,Kazuhiko Nakamura,Kazuo Yamada,Yoshimi Iwayama,Tomoko Toyota,Yasuhide Iwata,Katsuaki Suzuki,Toshiro Sugiyama,Masatsugu Tsujii,Takeo Yoshikawa,Norio Mori +11 more
TL;DR: This study provides strong genetic evidence of PCDHA as a potential candidate gene for autism, withstanding multiple testing corrections in multiplex families.