T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Genetic analysis of the glyoxalase system in schizophrenia
Fabian N. Bangel,Kazuo Yamada,Makoto Arai,Yoshimi Iwayama,Shabeesh Balan,Tomoko Toyota,Yasuhide Iwata,Katsuaki Suzuki,Mitsuru Kikuchi,Tasuku Hashimoto,Nobuhisa Kanahara,Norio Mori,Masanari Itokawa,Oliver Stork,Takeo Yoshikawa +14 more
TL;DR: The findings suggest that an explanation of elevated carbonyl stress in a substantial part of patients with schizophrenia will require the examination of a much larger cohort to detect risk alleles with weak effect size and/or other risk factors.
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An integrated physical map of 18p11.2: a susceptibility region for bipolar disorder.
Lisa E. Esterling,T Cox Matise,Alan R. Sanders,Takeo Yoshikawa,Joan Overhauser,Elliot S. Gershon,M T Moskowitz,Sevilla D. Detera-Wadleigh +7 more
TL;DR: To facilitate positional cloning of a susceptibility gene, a combination of mapping reagents was used to construct a high resolution physical map of the region including sequence tag sites (STSs) and expressed sequence tags (ESTs), which will be an important tool in providing loci for contig construction and positional candidates for mutation screening.
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Deletion of a consensus oestrogen response element half-site in the glucocorticoid receptor of human multiple myeloma
Jayaprakash D. Karkera,Susan E. Taymans,Gordon Turner,Takeo Yoshikawa,Sevilla D. Detera-Wadleigh,Robert G. Wadleigh +5 more
TL;DR: An amplified fragment from the 3′ untranslated region displayed an aberrant migration by PCR–single‐stranded conformational polymorphism (PCR‐SSCP) analysis, and the mutant allele had a deletion of an 8 base pair sequence containing a half‐site of an oestrogen response element.
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GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder.
Taro Kishi,Hiroshi Ichinose,Reiji Yoshimura,Yasuhisa Fukuo,Tsuyoshi Kitajima,Toshiya Inada,Hiroshi Kunugi,Tadafumi Kato,Takeo Yoshikawa,Hiroshi Ujike,Giovanna M. Musso,Wakako Umene-Nakano,Jun Nakamura,Norio Ozaki,Nakao Iwata +14 more
TL;DR: Results suggest that GCH1 may predict response to SSRI in MDD in the Japanese population, and a replication study using larger samples may be required for conclusive results.
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Association of transcription factor gene LMX1B with autism.
Ismail Thanseem,Kazuhiko Nakamura,Ayyappan Anitha,Shiro Suda,Kazuo Yamada,Yoshimi Iwayama,Tomoko Toyota,Masatsugu Tsujii,Masatsugu Tsujii,Yasuhide Iwata,Katsuaki Suzuki,Hideo Matsuzaki,Keiko Iwata,Toshiro Sugiyama,Takeo Yoshikawa,Norio Mori +15 more
TL;DR: This is the first report on the association of LMX1B with autism, though it should be viewed with some caution considering the modest associations reported, and is likely to be mediated through a seretoninergic mechanism.