T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
Ryoichi Arai,Kaori Ito,Tetsuo Ohnishi,Hisako Ohba,Ryogo Akasaka,Yoshitaka Bessho,Kyoko Hanawa-Suetsugu,Takeo Yoshikawa,Mikako Shirouzu,Shigeyuki Yokoyama +9 more
TL;DR: The crystal structures of human IMPA2 are useful for understanding the effect of nonsynonymous polymorphism reported in IMPA1, and will contribute to further functional analyses of IMPA3 that potentially predisposes to the vulnerabilities of bipolar disorder, schizophrenia, and febrile seizures.
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Case-control association study of human netrin G1 gene in Japanese schizophrenia
Masayuki Fukasawa,Mika Aoki,Mika Aoki,Kazuo Yamada,Yoshimi Iwayama-Shigeno,Hitomi Takao,Joanne M.A. Meerabux,Tomoko Toyota,Tomoko Toyota,Toru Nishikawa,Takeo Yoshikawa +10 more
TL;DR: Findings suggest that netrin G1 or a nearby gene may contribute to the overall genetic risk for schizophrenia.
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The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.
Kazutaka Ohi,Ryota Hashimoto,Yuka Yasuda,Tetsuhiko Yoshida,Hidetoshi Takahashi,Naomi Iike,Masao Iwase,Kouzin Kamino,Kouzin Kamino,Ryouhei Ishii,Hiroaki Kazui,Motoyuki Fukumoto,Hironori Takamura,Hidenaga Yamamori,Michiyo Azechi,Koji Ikezawa,Hitoshi Tanimukai,Shinji Tagami,Takashi Morihara,Masayasu Okochi,Kazuo Yamada,Shusuke Numata,Masashi Ikeda,Toshihisa Tanaka,Takashi Kudo,Shu-ichi Ueno,Takeo Yoshikawa,Tetsuro Ohmori,Nakao Iwata,Norio Ozaki,Masatoshi Takeda +30 more
TL;DR: It is concluded that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations.
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Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia.
Mizuho Takeshita,Kazuo Yamada,Eiji Hattori,Yoshimi Iwayama,Tomoko Toyota,Yasuhide Iwata,Kenji J. Tsuchiya,Genichi Sugihara,Kenji Hashimoto,Hiroyuki Watanabe,Masaomi Iyo,Mitsuru Kikuchi,Yuji Okazaki,Takeo Yoshikawa,Takeo Yoshikawa +14 more
TL;DR: It is suggested that PLXNA2 confers a varying genetic risk for schizophrenia among different populations, as well as linkage analysis or association tests (allelic and haplotypic transmission disequilibrium tests).
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Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
Chihiro Kakiuchi,Mizuho Ishiwata,Shinichiro Nanko,Hiroshi Kunugi,Yoshio Minabe,Kazuhiko Nakamura,Norio Mori,Kumiko Fujii,Kazuo Yamada,Takeo Yoshikawa,Tadafumi Kato +10 more
TL;DR: Genetic association of ATF4 and ATF5 genes with bipolar disorder by a case-control study in Japanese population and transmission disequilibrium test and gene expression analysis in lymphoblastoid cells did not find any significant association, and the role of these genes in the pathophysiology of bipolar disorder is suggested.