T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects.
A-M Lepagnol-Bestel,G. Maussion,Bernadett Boda,Ana Cardona,Yoshimi Iwayama,A-L Delezoide,J-M Moalic,Dominique Muller,Brian Dean,Takeo Yoshikawa,P. Gorwood,Joseph D. Buxbaum,Nicolas Ramoz,Michel Simonneau +13 more
TL;DR: The findings suggest that SLC25A12 overexpression may be involved in the pathophysiology of autism, modifying neuronal networks in specific subregions, such as the dorsolateral prefrontal cortex and fusiform gyrus, at both pre- and postnatal stages.
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Screening for 22q11 deletions in a schizophrenia population
Tadao Arinami,Tsuyuka Ohtsuki,K. Takase,Hiromitsu Shimizu,Takeo Yoshikawa,H. Horigome,Junko Nakayama,Michio Toru +7 more
TL;DR: The findings establish the existence of physically near-normal individuals with 22q11.2 deletion among learning disabled or mildly retarded persons with schizophrenia, and indicate that 22q 11.2 deletions does not contribute substantially to the development of schizophrenia in general.
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Altered RNA editing of serotonin 2C receptor in a rat model of depression.
TL;DR: It is revealed that altered RNA editing in the LH rats and by antidepressants was not explained by altered expression of RNA editing enzymes or their substrates (adenosine deaminases that act on RNA, H TR2C, and spliced form of HTR2C).
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Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.
Ayyappan Anitha,Kazuhiko Nakamura,Kazuo Yamada,Shiro Suda,Ismail Thanseem,Masatsugu Tsujii,Masatsugu Tsujii,Yoshimi Iwayama,Eiji Hattori,Tomoko Toyota,Taishi Miyachi,Yasuhide Iwata,Katsuaki Suzuki,Hideo Matsuzaki,Masayoshi Kawai,Yoshimoto Sekine,Kenji J. Tsuchiya,Genichi Sugihara,Yasuomi Ouchi,Toshiro Sugiyama,Keita Koizumi,Haruhiro Higashida,Nori Takei,Takeo Yoshikawa,Norio Mori +24 more
TL;DR: It is suggested that abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment, in the pathogenesis of autism.
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Preliminary genome-wide association study of bipolar disorder in the Japanese population.
Eiji Hattori,Tomoko Toyota,Yuichi Ishitsuka,Yoshimi Iwayama,Kazuo Yamada,Hiroshi Ujike,Yukitaka Morita,Masafumi Kodama,Kenji Nakata,Yoshio Minabe,Yoshio Minabe,Kazuhiko Nakamura,Yasuhide Iwata,Nori Takei,Norio Mori,Hiroshi Naitoh,Yoshio Yamanouchi,Nakao Iwata,Norio Ozaki,Tadafumi Kato,Toru Nishikawa,Atsushi Kashiwa,Mika Suzuki,Kunihiko Shioe,Manabu Shinohara,Masami Hirano,Shinichiro Nanko,Akihisa Akahane,Mikako Ueno,Naoshi Kaneko,Yuichiro Watanabe,Toshiyuki Someya,Kenji Hashimoto,Masaomi Iyo,Masanari Itokawa,Makoto Arai,Masahiro Nankai,Toshiya Inada,Sumiko Yoshida,Hiroshi Kunugi,Michiko Nakamura,Yoshimi Iijima,Yuji Okazaki,Teruhiko Higuchi,Takeo Yoshikawa +44 more
TL;DR: A two‐stage genome‐wide association study of bipolar disorder in Japanese cohorts, which is the first GWAS of BD in the Japanese population, and 89 markers remained nominally significant with the same allele being consistently over‐represented in both the first and the follow‐up stages.