T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia
Eiji Hattori,Mizuho Nakajima,Kazuo Yamada,Yoshimi Iwayama,Tomoko Toyota,Naruya Saitou,Takeo Yoshikawa +6 more
TL;DR: This study suggests that the VNTR variation does not have an effect large enough to cause either selection or a detectable association with schizophrenia in a study of samples of moderate size.
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Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.
Tadahiro Shimazu,Tamio Furuse,Shabeesh Balan,Ikuko Yamada,Shuzo Okuno,Hiroko Iwanari,Takehiro Suzuki,Takao Hamakubo,Naoshi Dohmae,Takeo Yoshikawa,Shigeharu Wakana,Yoichi Shinkai +11 more
TL;DR: It is shown that Mettl20 knockout mice fed a ketogenic diet had higher oxygen consumption and heat production and a subsequent cold tolerance test conducted after 24 h of fasting indicated that the KO mice had a better ability to maintain their body temperature in cold environments.
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Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia
Kayoko Esaki,Shabeesh Balan,Yoshimi Iwayama,Chie Shimamoto-Mitsuyama,Yoshio Hirabayashi,Brian Dean,Brian Dean,Takeo Yoshikawa +7 more
TL;DR: It is suggested that an altered S1P metabolism may underlie the deficits in oligodendrocyte differentiation and myelin formation, leading to the structural and molecular abnormalities of white matter reported in schizophrenia.
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Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.
Motoko Maekawa,Tetsuo Ohnishi,Kenji Hashimoto,Akiko Watanabe,Yoshimi Iwayama,Hisako Ohba,Eiji Hattori,Kazuo Yamada,Takeo Yoshikawa +8 more
TL;DR: In this paper, a quantitative trait loci analysis using C57BL/6 (B6) mice with better PPI performance and C3H/He (C3) with lower PPI score was performed to determine which gene is likely to explain the PPI difference and whether the gene is potentially relevant to schizophrenia.
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An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders
Shinji Matsunaga,Masashi Ikeda,Taro Kishi,Yasuhisa Fukuo,Branko Aleksic,Reiji Yoshimura,Tomo Okochi,Yoshio Yamanouchi,Yoko Kinoshita,Kunihiro Kawashima,Wakako Umene-Nakano,Toshiya Inada,Hiroshi Kunugi,Tadafumi Kato,Takeo Yoshikawa,Hiroshi Ujike,Jun Nakamura,Norio Ozaki,Tsuyoshi Kitajima,Nakao Iwata +19 more
TL;DR: The results do not support that genetic variation in CS NK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.