T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.
Tetsuo Ohnishi,Kazuo Yamada,Hisako Ohba,Yoshimi Iwayama,Tomoko Toyota,Eiji Hattori,Toshiya Inada,Hiroshi Kunugi,Masahiko Tatsumi,Norio Ozaki,Nakao Iwata,Kaoru Sakamoto,Yoshimi Iijima,Yasuhide Iwata,Kenji J. Tsuchiya,Genichi Sugihara,Shinichiro Nanko,Noriko Osumi,Sevilla D. Detera-Wadleigh,Tadafumi Kato,Takeo Yoshikawa +20 more
TL;DR: It is suggested that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA1 levels in the brain, albeit the genetic effect varies among populations.
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Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.
Motoko Maekawa,Yoshimi Iwayama,Ryoichi Arai,Kazuhiko Nakamura,Tetsuo Ohnishi,Tomoko Toyota,Masatsugu Tsujii,Yuji Okazaki,Noriko Osumi,Yuji Owada,Norio Mori,Takeo Yoshikawa +11 more
TL;DR: The possible roles of brain-expressed FABPs in autism are examined, focusing primarily on potentially functional polymorphisms (that is, missense polymorphisms), and the loss of charge and salt bridge, caused by the Asp3-to-Gly3, may affect stability of the FABP3 protein.
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A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient
Motoko Maekawa,Yoshimi Iwayama,Kazuhiko Nakamura,Miho Sato,Tomoko Toyota,Tetsuo Ohnishi,Kazuo Yamada,Taishi Miyachi,Masatsugu Tsujii,Masatsugu Tsujii,Eiji Hattori,Nobuo Maekawa,Noriko Osumi,Norio Mori,Takeo Yoshikawa +14 more
TL;DR: The resequenced exons and flanking introns of PAX6 in 285 autistic patients in the Japanese, with the possibility that novel mutations may underlie autism, and found one missense mutation that was found in a patient: 136C>G (Leu46Val).
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Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility.
Kazuhiko Nakamura,Yasuhide Iwata,Ayyappan Anitha,Taishi Miyachi,Tomoko Toyota,Satoru Yamada,Masatsugu Tsujii,Masatsugu Tsujii,Kenji J. Tsuchiya,Yoshimi Iwayama,Kazuo Yamada,Eiji Hattori,Hideo Matsuzaki,Kaori Matsumoto,Katsuaki Suzuki,Shiro Suda,Kiyokazu Takebayashi,Nori Takei,Hironobu Ichikawa,Toshiro Sugiyama,Takeo Yoshikawa,Norio Mori +21 more
TL;DR: A possible role of STX1A in the pathogenesis of autism is suggested using data from a trio association study using DNA samples from Japanese trios with autistic probands to examine the association of this protein with autism.
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The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis
Taro Kishi,Reiji Yoshimura,Yasuhisa Fukuo,Tsuyoshi Kitajima,Tomo Okochi,Shinji Matsunaga,Toshiya Inada,Hiroshi Kunugi,Tadafumi Kato,Takeo Yoshikawa,Hiroshi Ujike,Wakako Umene-Nakano,Jun Nakamura,Norio Ozaki,Alessandro Serretti,Christoph U. Correll,Nakao Iwata +16 more
TL;DR: Data suggest that CLOCK does not play a major role in the pathophysiology of mood disorders, and does not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis.