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Volker Ruppert
Researcher at University of Marburg
Publications - 60
Citations - 1567
Volker Ruppert is an academic researcher from University of Marburg. The author has contributed to research in topics: Dilated cardiomyopathy & Myocarditis. The author has an hindex of 19, co-authored 59 publications receiving 1341 citations. Previous affiliations of Volker Ruppert include University Hospital of Giessen and Marburg.
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Journal ArticleDOI
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
Eric Villard,Claire Perret,Françoise Gary,Carole Proust,Gilles Dilanian,Christian Hengstenberg,Volker Ruppert,Eloisa Arbustini,Thomas Wichter,Marine Germain,Olivier Dubourg,Luigi Tavazzi,Marie-Claude Aumont,Pascal DeGroote,Laurent Fauchier,Jean-Noël Trochu,Pierre Gibelin,Jean-François Aupetit,Klaus Stark,Jeanette Erdmann,Roland Hetzer,Angharad M. Roberts,Paul J.R. Barton,Vera Regitz-Zagrosek,Uzma Aslam,Laëtitia Duboscq-Bidot,Matthias Meyborg,Bernhard Maisch,Hugo Madeira,Anders Waldenström,Enrique Galve,John G.F. Cleland,Richard Dorent,Gérard Roizès,Tanja Zeller,Stefan Blankenberg,Alison H. Goodall,Stuart A. Cook,Stuart A. Cook,D.A. Tregouet,Laurence Tiret,Richard Isnard,Michel Komajda,Philippe Charron,François Cambien +44 more
TL;DR: The results show that rare mutations in BAG3 contribute to monogenic forms of the disease, while common variant(s) in the same gene are implicated in sporadic DCM.
Journal ArticleDOI
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Benjamin Meder,Frank Rühle,Tanja Weis,Georg Homuth,Andreas Keller,Jennifer Franke,Barbara Peil,Justo Lorenzo Bermejo,Karen S. Frese,Andreas Huge,Anika Witten,Britta Vogel,Jan Haas,Uwe Völker,Florian Ernst,Alexander Teumer,Philipp Ehlermann,Christian Zugck,Frauke Friedrichs,Heyo K. Kroemer,Marcus Dörr,Wolfgang Hoffmann,Bernhard Maisch,Sabine Pankuweit,Volker Ruppert,Thomas Scheffold,Uwe Kühl,H.P. Schultheiss,Reinhold Kreutz,Georg Ertl,Christiane E. Angermann,Philippe Charron,Eric Villard,Françoise Gary,Richard Isnard,Michel Komajda,Matthias Lutz,Thomas Meitinger,Moritz F. Sinner,Moritz F. Sinner,Moritz F. Sinner,H.-Erich Wichmann,Michael Krawczak,Boris Ivandic,Dieter Weichenhan,Goetz Gelbrich,Nour Eddine El-Mokhtari,Stefan Schreiber,Stephan B. Felix,Gerd Hasenfuß,Arne Pfeufer,Norbert Hubner,Stefan Kääb,Eloisa Arbustini,Wolfgang Rottbauer,Wolfgang Rottbauer,Norbert Frey,Norbert Frey,Monika Stoll,Hugo A. Katus +59 more
TL;DR: The present study reveals a novel genetic susceptibility locus that clearly underlines the role of genetically driven, inflammatory processes in the pathogenesis of idiopathic DCM.
Journal ArticleDOI
Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy.
Laëtitia Duboscq-Bidot,Laëtitia Duboscq-Bidot,Philippe Charron,Philippe Charron,Volker Ruppert,Laurent Fauchier,Anette Richter,Luigi Tavazzi,Eloisa Arbustini,Thomas Wichter,Bernard Maisch,Michel Komajda,Michel Komajda,Richard Isnard,Eric Villard,Eric Villard +15 more
TL;DR: On the basis of genetic and functional analysis of CARP mutations, ANKRD1 is identified as a new gene associated with DCM, accounting for approximately 2% of cases.
Journal ArticleDOI
A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy.
Maximilian G. Posch,Maximilian G. Posch,Matthias J Posch,Christian Geier,Christian Geier,Bettina Erdmann,Wolf Mueller,Anette Richter,Volker Ruppert,Sabine Pankuweit,Bernhard Maisch,Andreas Perrot,Andreas Perrot,Jens Buttgereit,Rainer Dietz,Rainer Dietz,Wilhelm Haverkamp,Cemil Özcelik,Cemil Özcelik +18 more
TL;DR: The DSG2-V55M polymorphism is identified as a novel risk variant for DCM associated with shortened desmosomes of the cardiac intercalated disc.
Journal ArticleDOI
Identification of mutational hot spots in LMNA encoding lamin A/C in patients with familial dilated cardiomyopathy
Andreas Perrot,Shwan Hussein,Volker Ruppert,Hartmut H.-J. Schmidt,Manfred Wehnert,Nguyen Thuy Duong,Maximilian G. Posch,Anna N. Panek,Rainer Dietz,Ingrid Kindermann,Michael Böhm,Aleksandra Michalewska-Włudarczyk,Anette Richter,Bernhard Maisch,S. Pankuweit,Cemil Özcelik +15 more
TL;DR: It was remarkable that four mutations represent LMNA hot spots, which are important for lamin B interaction and lamin A/C dimerization in DCM patients with LMNA mutations.