T
Tomasz Szczepański
Researcher at Medical University of Silesia
Publications - 267
Citations - 10296
Tomasz Szczepański is an academic researcher from Medical University of Silesia. The author has contributed to research in topics: Minimal residual disease & Gene rearrangement. The author has an hindex of 47, co-authored 238 publications receiving 8935 citations. Previous affiliations of Tomasz Szczepański include University of Silesia in Katowice & Wrocław Medical University.
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Journal ArticleDOI
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes.
J. J. M. Van Dongen,Ludovic Lhermitte,S Böttcher,Julia Almeida,V H J van der Velden,Juan Flores-Montero,Andy C. Rawstron,Vahid Asnafi,Quentin Lecrevisse,Paulo Sérgio Lucio,Ester Mejstrikova,Tomasz Szczepański,Tomas Kalina,R de Tute,Monika Brüggemann,Lukasz Sedek,M Cullen,Anthonie Willem Langerak,Alexandre de Mendonça,Elizabeth Macintyre,Marta Martin-Ayuso,Ondrej Hrusak,M B Vidriales,Alberto Orfao +23 more
TL;DR: The EuroFlow studies resulted in validated and flexible 8-color antibody panels for multidimensional identification and characterization of normal and aberrant cells, optimally suited for immunophenotypic screening and classification of hematological malignancies.
Journal ArticleDOI
The MLL recombinome of acute leukemias.
Christian Meyer,Björn Schneider,S. Jakob,Sabine Strehl,A. Attarbaschi,Susanne Schnittger,Claudia Schoch,M W J C Jansen,J. J. M. Van Dongen,M L den Boer,Rob Pieters,M. G. Ennas,Emanuele Angelucci,Ulrike Koehl,Johann Greil,Frank Griesinger,U. Zur Stadt,C Eckert,Tomasz Szczepański,Felix Niggli,Beat W. Schäfer,Helena Kempski,Hugh J.M. Brady,Jan Zuna,Jan Trka,Luca Lo Nigro,Andrea Biondi,Eric Delabesse,Elizabeth Macintyre,Martin Stanulla,Martin Schrappe,Oskar A. Haas,Thomas Burmeister,Theodor Dingermann,T. Klingebiel,Rolf Marschalek +35 more
TL;DR: The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) was determined and several new TPGs were identified and two new MLL rearrangements are now characterized at the molecular level.
Journal ArticleDOI
Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects.
V H J van der Velden,Andreas Hochhaus,Giovanni Cazzaniga,Tomasz Szczepański,Jean Gabert,J. J. M. Van Dongen +5 more
TL;DR: The interpretation of RQ-PCR MRD data needs standardized criteria and reporting of MRDData needs international uniformity, and several European networks have now been established and common guidelines for data analysis and for reporting ofMRD data are being developed.
Journal ArticleDOI
A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.
Rob Pieters,Martin Schrappe,Paola De Lorenzo,Ian Hann,Giulio Rossi,Maria S. Felice,Liisa Hovi,Thierry Leblanc,Tomasz Szczepański,Alina Ferster,Gritta Janka,Jeffrey E. Rubnitz,Lewis B. Silverman,Jan Stary,Myriam Campbell,Chi Kong Li,Georg Mann,Ram Suppiah,Andrea Biondi,Ajay Vora,Maria Grazia Valsecchi +20 more
TL;DR: Patients treated with the hybrid protocol, and especially those who responded poorly to prednisone, had higher EFS than most reported outcomes for treatment of infant ALL, and Delayed intensification of chemotherapy did not benefit patients.
Journal ArticleDOI
The MLL recombinome of acute leukemias in 2017
Christian Meyer,Thomas Burmeister,Daniela Gröger,Grigory Tsaur,L Fechina,Aline Renneville,Rosemary Sutton,Nicola C. Venn,Mariana Emerenciano,Maria S. Pombo-de-Oliveira,C Barbieri Blunck,B Almeida Lopes,Jan Zuna,Jan Trka,Paola Ballerini,Hélène Lapillonne,M. De Braekeleer,Giovanni Cazzaniga,L Corral Abascal,V H J van der Velden,Eric Delabesse,T S Park,S H Oh,Maria Luiza Macedo Silva,T Lund-Aho,Vesa Juvonen,Andrew S. Moore,Olaf Heidenreich,Josef Vormoor,Elena Zerkalenkova,Yulia Olshanskaya,Clara Bueno,Clara Bueno,Pablo Menendez,Pablo Menendez,Andrea Teigler-Schlegel,U zur Stadt,Jana Lentes,Gudrun Göhring,Anatoly Kustanovich,Olga Aleinikova,Beat W. Schäfer,S Kubetzko,Hans O. Madsen,Bernd Gruhn,X Duarte,Paula Gameiro,Eric Lippert,A Bidet,J M Cayuela,Emmanuelle Clappier,Cristina N. Alonso,Christian M. Zwaan,M M van den Heuvel-Eibrink,Shai Izraeli,Shai Izraeli,L. Trakhtenbrot,L. Trakhtenbrot,P Archer,Jeremy Hancock,Anja Möricke,Julia Alten,Martin Schrappe,Martin Stanulla,Sabine Strehl,Andishe Attarbaschi,Michael Dworzak,Oskar A. Haas,Renate Panzer-Grümayer,Lukasz Sedek,Tomasz Szczepański,Aurélie Caye,L Suarez,Hélène Cavé,Rolf Marschalek +74 more
TL;DR: This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.