V
Valentin Wittmann
Researcher at University of Konstanz
Publications - 129
Citations - 3199
Valentin Wittmann is an academic researcher from University of Konstanz. The author has contributed to research in topics: Glycosyl & Glycoprotein. The author has an hindex of 32, co-authored 125 publications receiving 2900 citations. Previous affiliations of Valentin Wittmann include Russian Academy of Sciences & Technische Universität München.
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Journal ArticleDOI
Structural basis of multivalent binding to wheat germ agglutinin.
David Schwefel,Caroline Maierhofer,Johannes G. Beck,Sonja Seeberger,Kay Diederichs,Heiko M. Möller,Wolfram Welte,Valentin Wittmann +7 more
TL;DR: The findings show that bridging adjacent protein binding sites by multivalent ligands is a valid strategy to find high-affinity protein ligands and that even subtle changes of the linker structure can have a significant impact on the binding affinity.
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1H-Tetrazole as Catalyst in Phosphomorpholidate Coupling Reactions: Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose
Valentin Wittmann,Chi-Huey Wong +1 more
TL;DR: Comparative kinetic investigations suggest that tetrazole acts as an acid and as a nucleophilic catalyst in the pyrophosphate bond formation.
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Two‐Color Glycan Labeling of Live Cells by a Combination of Diels–Alder and Click Chemistry
Andrea Niederwieser,Anne-Katrin Späte,Long Duc Nguyen,Christian Jüngst,Werner Reutter,Valentin Wittmann +5 more
TL;DR: This work shows that ManNAc derivatives containing a terminal alkene in the acyl side chain are metabolically incorporated into cell-surface sialic acids and can subsequently be labeled by the DARinv, and identifies monosubstituted (terminal) alkenes as a new class of chemical reporters.
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Bridging lectin binding sites by multivalent carbohydrates.
TL;DR: This article summarizes recent examples of chelating lectin ligands of different size and suggests that chelates binding of the discussed ligands is likely, but experimental proof, for example by X-ray crystallography, is limited to only a few cases.
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One-pot procedure for diazo transfer and azide-alkyne cycloaddition: triazole linkages from amines.
TL;DR: A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-Catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported, which achieves excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates.