Wangheng Hou

TL;DR: In this study, a G protein-deficient vesicular stomatitis virus (VSVdG) bearing a truncated spike protein was compared to that bearing the full-length spike protein of SARS-CoV-2 and showed much higher efficiency and could facilitate the development of new drugs and vaccines.

TL;DR: Typical acute antibody response is induced during the SARS-CoV-2 infection and the serology testing provides important complementation to RNA test for pathogenic specific diagnosis and helpful information to evaluate the adapted immunity status of patient.

TL;DR: The chemical features, suborganelle distribution and potential function of each protein using Flag-tagged protein expression system suggest that ZIKV generates 10 functional viral proteins that exhibit distinctive subcellular distribution in host cells.

TL;DR: The isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates are demonstrated and an immune-dominant neutralizing epitope is identified which can be exploited for vaccine development.

TL;DR: This new humanised mouse model recapitulates the liver cirrhosis induced by human HBV infection, thus providing research opportunities for understanding viral immune pathophysiology and testing antiviral therapies in vivo.