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Wolf H. Fridman
Researcher at University of Paris
Publications - 551
Citations - 60835
Wolf H. Fridman is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Receptor. The author has an hindex of 97, co-authored 525 publications receiving 48713 citations. Previous affiliations of Wolf H. Fridman include Queen Elizabeth Hospital Birmingham & Pasteur Institute.
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Journal ArticleDOI
Administration of fibroblast interferon to patients with advanced breast cancer: Possible effects on skin metastasis and on hormone receptors☆
Pierre Pouillart,Thao Palangie,M. Jouve,Garcia-Giralt E,Wolf H. Fridman,Henri Magdelenat,Ernesto Falcoff,Alfons Billiau +7 more
TL;DR: Although several types of metastases were monitored, only skin nodules consistently exhibited changes that were suggestive of a therapeutic effect of the treatment regimen: either a simple decrease in size of some nodules or central necrosis accompanied by an inflammatory reaction.
Journal ArticleDOI
Cytokines and Cancer
Eric Tartour,Wolf H. Fridman +1 more
TL;DR: The use of cytokines as anti-tumor agents has led to objective clinical responses in about 15-25% of patients with metastatic melanoma or renal cell carcinoma, which presents the basis for the development of promising immunotherapeutic approaches for cancer therapy.
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Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance
Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina,Damien Sène,Maria Radanova,Jacques Blouin,Lise Halbwachs-Mecarelli,Lise Halbwachs-Mecarelli,Marie-Agnès Dragon-Durey,Wolf H. Fridman,Véronique Frémeaux-Bacchi +10 more
TL;DR: The data infer that the binding of C1q to apoptotic cells in humans is insufficient to assure self-tolerance, and the opsonization capacity of C4 and C3 fragments has to be intact to fight infections and to prevent autoimmunity.
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Soluble Fc gamma receptors.
Wolf H. Fridman,Jean-Luc Teillaud,Caroline Bouchard,Christophe Teillaud,Anne Astier,Eric Tartour,Jérôme Galon,Claire Mathiot,Catherine Sautes +8 more
TL;DR: Soluble FCγ receptors have been identified in biological fluids of mice and humans and seem to be modified during the development of certain diseases, as for instance in multiple myeloma, where plasma concentrations oi soluble FCγKIll are correlated with the stage of the disease.
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Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.
TL;DR: T2D4, a T-cell hybrid, spontaneously secretes suppressive immunoglobulin factor(s), which bind selectively to the IgG1 or IgG2 subclasses and inhibit specifically the secretion of antibodies of the corresponding subclass.