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Wolf H. Fridman
Researcher at University of Paris
Publications - 551
Citations - 60835
Wolf H. Fridman is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Receptor. The author has an hindex of 97, co-authored 525 publications receiving 48713 citations. Previous affiliations of Wolf H. Fridman include Queen Elizabeth Hospital Birmingham & Pasteur Institute.
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Journal Article
Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens.
M E Esposito-Farese,Catherine Sautes,Sylvain Latour,Thomas Bieber,P Ohlmann,Wolf H. Fridman,J.-P. Cazenave,Jean-Luc Teillaud +7 more
TL;DR: The results suggest that, in vivo, murine dendritic epidermal Langerhans cells express membrane Fc gamma R, which increase their Ag-presenting capacity for IgG-complexed Ag, and release sFc gammaR, which might be able to modulate this Ag presentation.
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TRAF4 overexpression is a common characteristic of human carcinomas.
Sophie Camilleri-Broët,Sophie Camilleri-Broët,Isabelle Cremer,Marmey B,Eva Comperat,Franck Viguié,Josée Audouin,Rio Mc,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine H. Régnier +10 more
TL;DR: Tumor necrosis factor receptor (TNFR) associated factor 4 (TRAF4) was initially identified as a gene amplified and overexpressed in breast carcinomas and data support an oncogenic role for TRAF4.
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PD-L1 Expression and CD8+ T-cell Infiltrate are Associated with Clinical Progression in Patients with Node-positive Prostate Cancer.
Florent Petitprez,Nicola Fossati,Yann Vano,Massimo Freschi,Etienne Becht,Etienne Becht,Etienne Becht,Roberta Lucianò,Julien Calderaro,Julien Calderaro,Julien Calderaro,Tiffany Guédet,Tiffany Guédet,Tiffany Guédet,Laetitia Lacroix,Laetitia Lacroix,Laetitia Lacroix,Paola M.V. Rancoita,Francesco Montorsi,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Alberto Briganti,Claudio Doglioni,Matteo Bellone +27 more
TL;DR: It is found that expression of PD-L1 by tumor cells and a high density of CD8+ T cells in tumor are associated with a higher risk of clinical progression in men with node-positive prostate cancer.
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Molecular aspects of human FcγR interactions with IgG: Functional and therapeutic consequences
Sophie Sibéril,Charles-Antoine Dutertre,Charlotte Boix,Emmanuelle Bonnin,Renée Ménez,Enrico A. Stura,Sylvie Jorieux,Wolf H. Fridman,Jean-Luc Teillaud +8 more
TL;DR: The engineering of a new generation of monoclonal antibodies for therapeutic use with optimized effector functions is led to after detailed insights in the molecular mechanisms that govern IgG/FcgammaR interactions were obtained.
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Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation.
TL;DR: It is shown that a chimeric molecule having the transmembrane and intracytoplasmic domains of SIRPα could inhibit IgE-induced mediator secretion and cytokine synthesis by mast cells and can negatively regulate not only receptor tyrosine kinase-dependent cell proliferation but also ITAM- dependent cell activation.