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Wolf H. Fridman
Researcher at University of Paris
Publications - 551
Citations - 60835
Wolf H. Fridman is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Receptor. The author has an hindex of 97, co-authored 525 publications receiving 48713 citations. Previous affiliations of Wolf H. Fridman include Queen Elizabeth Hospital Birmingham & Pasteur Institute.
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Book ChapterDOI
Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.
Etienne Becht,Nicolas A. Giraldo,Claire Germain,Aurélien de Reyniès,Pierre Laurent-Puig,Jessica Zucman-Rossi,Marie-Caroline Dieu-Nosjean,Catherine Sautès-Fridman,Wolf H. Fridman +8 more
TL;DR: The description and the understanding of the immune and inflammatory landscape in human tumors are of paramount importance and completes the mutational, transcriptional, and epigenetic patterns of the malignant cells and open paths to understand how tumor cells shape their immune microenvironment and are shaped by the immune reaction.
Journal Article
Interleukin-18: biological properties and clinical implications
Sophie Lebel-Binay,Anne Berger,Franck Zinzindohoué,Paul-Henri Cugnenc,Nicolas Thiounn,Wolf H. Fridman,Franck Pages +6 more
TL;DR: This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role ofIL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.
Journal ArticleDOI
A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens.
Hélène Péré,Yves Montier,Jagadeesh Bayry,Françoise Quintin-Colonna,Françoise Quintin-Colonna,Nathalie Merillon,Estelle Dransart,Cécile Badoual,Alain Gey,Patrice Ravel,Elie Marcheteau,Frédéric Batteux,Federico Sandoval,Olivier Adotevi,Christopher Chiu,Sylvie Garcia,Corinne Tanchot,Yu-Chun Lone,Luís Carlos de Souza Ferreira,Brad H. Nelson,Douglas Hanahan,Wolf H. Fridman,Ludger Johannes,Eric Tartour +23 more
TL;DR: The ability of a CCR4 antagonist when combined with vaccines to break peripheral tolerance controlled by Tregs, a prerequisite for the induction of CD8(+) T cells against self Ags, is demonstrated.
Journal ArticleDOI
The high frequency of Complement Factor H-Related CFHR1 Gene Deletion is restricted to specific subgroups of patients with atypical Haemolytic Uraemic Syndrome
Marie-Agnès Dragon-Durey,Caroline Blanc,Florence Marliot,Chantal Loirat,Jacques Blouin,Catherine Sautès-Fridman,Wolf H. Fridman,Véronique Frémeaux-Bacchi +7 more
TL;DR: The results suggest that the CFHR1 deletion plays a secondary role in susceptibility to aHUS, restricted to the subgroups of patients presenting with anti-FH autoantibodies or, to a lesser degree, CFI mutation.
Journal ArticleDOI
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina,Mathieu Jablonski,Mathieu Jablonski,Mathieu Jablonski,Christophe Hue,Christophe Hue,Christophe Hue,Jacques Blouin,Jordan D. Dimitrov,Jordan D. Dimitrov,Jordan D. Dimitrov,Marie-Agnès Dragon-Durey,Mathieu Cayla,Mathieu Cayla,Mathieu Cayla,Wolf H. Fridman,Marie-Alice Macher,David Ribes,Luc Moulonguet,Lionel Rostaing,Simon C. Satchell,Peter W. Mathieson,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Chantal Loirat,Catherine H. Régnier,Catherine H. Régnier,Catherine H. Régnier,Lise Halbwachs-Mecarelli,Véronique Frémeaux-Bacchi +32 more
TL;DR: It is demonstrated for the first time that factor B mutations lead to enhanced C3-fragment deposition on quiescent and adherent human glomerular cells (GEnCs) and human umbilical vein endothelial cells (HUVECs), together with the formation of sC5b-9 complexes.