Wolf H. Fridman

TL;DR: The infusion of Fcγ fragments is an efficient treatment of acute ITP in children and strengthens the hypothesis that F cγR blockade is the main mechanism of action of IVIG in ITP, although other immunoregulatory mechanisms triggered by the presence of increased sCD16 concentrations in serum could be involved in the clinical benefit observed.

TL;DR: It was shown that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels, and behaves like a T-cell-specific cytokine with paradoxical tumor-promoting activity.

TL;DR: The critical components of the TME in solid tumours and how they shape the immune cell contexture are reviewed, and numerous studies evaluating its clinical significance are summarized from a prognostic and theranostic perspective.

TL;DR: Data integration and biomolecular network reconstruction is a powerful approach to uncover molecular mechanisms in colorectal cancer and shows the utility of this approach for the investigation of malignant tumors and other diseases.

TL;DR: In preclinical models, antiangiogenic molecules promoted intratumor trafficking of effector cells, enhance endogenous anti-tumor response, and synergyzed with immunotherapy protocols to cure established murine tumors warrant the development of clinical trials combining antiangIogenic drugs and immunotherapy.