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Wolf H. Fridman
Researcher at University of Paris
Publications - 551
Citations - 60835
Wolf H. Fridman is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Receptor. The author has an hindex of 97, co-authored 525 publications receiving 48713 citations. Previous affiliations of Wolf H. Fridman include Queen Elizabeth Hospital Birmingham & Pasteur Institute.
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Journal ArticleDOI
Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract.
Franck Pagès,Anne Berger,Sophie Lebel-Binay,Franck Zinzindohoué,Claire Danel,Bernard Piqueras,Océane Carriere,Nicolas Thiounn,Paul H. Cugnenc,Wolf H. Fridman +9 more
TL;DR: The investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD) show clear patterns of action on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation.
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Src Homology 2 Domain-containing Inositol 5-Phosphatase 1 Mediates Cell Cycle Arrest by FcγRIIB
TL;DR: The results demonstrate that FcγRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively, but that, in the absence ofSHIP1, F cγR IIB can use other effectors that specifically inhibit cell proliferation.
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Impaired th1/tc1 cytokine production of tumor-infiltrating lymphocytes in a model of primary intraocular B-cell lymphoma.
Valérie Touitou,Cécile Daussy,Bahram Bodaghi,Serge Camelo,Yvonne de Kozak,Phuc LeHoang,Marie-Christine Naud,Audrey Varin,B. Thillaye-Goldenberg,Hélène Merle-Béral,Wolf H. Fridman,Catherine Sautès-Fridman,Sylvain Fisson +12 more
TL;DR: The results suggest that T-cells from intraocular B-lymphomas are characterized by a Th1/Tc1-like profile that could be partially inhibited in vivo, and raise the possibility of a T-cell immunostimulation to reactivate the Th1-Tc 1-LYmphocytes and improve intraocular antitumoral immunity.
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Therapeutic Targeting of the Colorectal Tumor Stroma
TL;DR: The features of the colorectal tumor stroma that associate with outcomes of patients are reviewed and potential therapeutic agents that target these features are discussed.
Journal Article
Binding Site of Human IgG Subclasses and Their Domains for Fc Receptors of Activated Murine T Cells
TL;DR: It was demonstrated that the three human IgG subclasses shown to be cytophilic share common or linked receptors, which were not associated with the H-2 alloantigens.