J
Jessica Cassin
Researcher at Johns Hopkins University School of Medicine
Publications - 3
Citations - 376
Jessica Cassin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Dorsal root ganglion & Axon. The author has an hindex of 2, co-authored 2 publications receiving 243 citations.
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Journal ArticleDOI
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Yi Lan Weng,Yi Lan Weng,Xu Wang,Ran An,Jessica Cassin,Caroline Vissers,Yuanyuan Liu,Yajing Liu,Tianlei Xu,Xinyuan Wang,Samuel Zheng Hao Wong,Jessica Joseph,Louis C. Dore,Qiang Dong,Wei Zheng,Peng Jin,Hao Wu,Bin Shen,Xiaoxi Zhuang,Chuan He,Kai Liu,Hongjun Song,Guo Li Ming +22 more
TL;DR: It is reported that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG).
Journal ArticleDOI
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Yi Lan Weng,Ran An,Ran An,Jessica Cassin,Jessica Joseph,Ruifa Mi,Chen Wang,Chun Zhong,Seung Gi Jin,Gerd P. Pfeifer,Alfonso Bellacosa,Xinzhong Dong,Ahmet Hoke,Zhigang He,Hongjun Song,Guo Li Ming +15 more
TL;DR: This study shows that peripheral sciatic nerve lesion in adult mice leads to elevated levels of Tet3 and 5-hydroxylmethylcytosine in dorsal root ganglion neurons, and suggests an epigenetic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adult mammalian nervous system.
Journal ArticleDOI
Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms
Jessica Cassin,Marianna Stamou,Kimberly Keefe,Ka I Sung,Celine Bojo,Karen J. Tonsfeldt,Rebecca A. Rojas,Vanessa Ferreira Lopes,Lacey Plummer,Kathryn B Salnikov,David L. Keefe Jr.,Metin Ozata,Myron Genel,Neoklis A. Georgopoulos,Janet E. Hall,William F. Crowley,Stephanie B. Seminara,Pamela L. Mellon,Ravi Balasubramanian +18 more
TL;DR: In this paper , the authors examined exome-sequencing data from a large, well-phenotyped cohort of patients with idiopathic hypogonadotropic hypogenetic hypogono-morphosis (IHH) for pathogenic SRY-box transcription factor 2 (SOX2) variants to investigate the underlying pathogenic SOX2 spectrum and its associated phenotypes.