Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Yi Lan Weng,Yi Lan Weng,Xu Wang,Ran An,Jessica Cassin,Caroline Vissers,Yuanyuan Liu,Yajing Liu,Tianlei Xu,Xinyuan Wang,Samuel Zheng Hao Wong,Jessica Joseph,Louis C. Dore,Qiang Dong,Wei Zheng,Peng Jin,Hao Wu,Bin Shen,Xiaoxi Zhuang,Chuan He,Kai Liu,Hongjun Song,Guo Li Ming +22 more
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TLDR
It is reported that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG).About:
This article is published in Neuron.The article was published on 2018-01-17 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Axon & Dorsal root ganglion.read more
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Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
TL;DR: This review highlights recent progress in understanding the function of N6-methyladenosine (m6A), the most abundant internal mark on eukaryotic mRNA, in light of the specific biological contexts of m6A effectors, and emphasizes the importance of context for RNA modification regulation and function.
Journal ArticleDOI
The role of m6A modification in the biological functions and diseases.
Xiulin Jiang,Xiulin Jiang,Baiyang Liu,Baiyang Liu,Zhi Nie,Zhi Nie,Zhi Nie,Lincan Duan,Qiuxia Xiong,Zhixian Jin,Cui-Ping Yang,Yongbin Chen,Yongbin Chen +12 more
TL;DR: In this paper, the authors discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems.
Journal ArticleDOI
m 6 A facilitates hippocampus-dependent learning and memory through YTHDF1
Hailing Shi,Xuliang Zhang,Xuliang Zhang,Yi Lan Weng,Zongyang Lu,Yajing Liu,Zhike Lu,Jianan Li,Piliang Hao,Yu Zhang,Feng Zhang,You Wu,Jary Y. Delgado,Yijing Su,Meera J. Patel,Xiaohua Cao,Bin Shen,Xingxu Huang,Guo Li Ming,Xiaoxi Zhuang,Hongjun Song,Chuan He,Tao Zhou +22 more
TL;DR: It is shown that, through its binding protein YTHDF1, m6A promotes protein translation of target transcripts in response to neuronal stimuli in the adult mouse hippocampus, thereby facilitating learning and memory.
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Intrinsic mechanisms of neuronal axon regeneration
Marcus Mahar,Valeria Cavalli +1 more
TL;DR: The mechanisms that initiate and coordinate the programme of transcriptional and epigenetic changes that enable axon regeneration in the peripheral nervous system are described.
Journal ArticleDOI
Accurate detection of m6A RNA modifications in native RNA sequences
Huanle Liu,Oguzhan Begik,Oguzhan Begik,Morghan C. Lucas,Jose Miguel Ramirez,Christopher E. Mason,Christopher E. Mason,David Wiener,Schraga Schwartz,John S. Mattick,John S. Mattick,John S. Mattick,Martin A. Smith,Martin A. Smith,Eva Maria Novoa +14 more
TL;DR: It is demonstrated that using direct RNA sequencing, N 6-methyladenosine (m6A) RNA modifications can be detected with high accuracy, in the form of systematic errors and decreased base-calling qualities, and open avenues to investigate the biological roles of RNA modifications in their native RNA context.
References
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Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
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TL;DR: The Spliced Transcripts Alignment to a Reference (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequential maximum mappable seed search in uncompressed suffix arrays followed by seed clustering and stitching procedure outperforms other aligners by a factor of >50 in mapping speed.
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
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TL;DR: The findings suggest that RNA decoration by m6A has a fundamental role in regulation of gene expression, and a subset of stimulus-dependent, dynamically modulated sites is identified.