Yi Yan Yang

TL;DR: Clinical micrographs reveal that the polyvinylalcohol (PVA as an emulsifier) concentration in the external water phase strongly influences drug distribution within microspheres and release profiles, and the presence of PVA in the internal water phase enhances the stabilization of inner water droplets against coalescence.

TL;DR: Cationic core–shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge.

TL;DR: It is shown that a novel class of core-shell nanoparticles formed by self-assembly of an amphiphilic peptide have strong antimicrobial properties against a range of bacteria, yeasts and fungi and can cross the blood-brain barrier and suppress bacterial growth in infected brains.

TL;DR: It is demonstrated that the nanoparticles disrupt microbial walls/membranes selectively and efficiently, thus inhibiting the growth of Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and fungi, without inducing significant haemolysis over a wide range of concentrations.

TL;DR: Different approaches to fabricate polymeric nanostructures of various shapes are reviewed, a comprehensive summary on the current understandings of the influence of nanostructure with different shapes on important biological processes in drug delivery is provided, and future perspectives for the development of nanstructures with well-defined shapes for drug delivery are discussed.