Z
Z. Hong Zhou
Researcher at University of California, Los Angeles
Publications - 251
Citations - 13342
Z. Hong Zhou is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Capsid & Biology. The author has an hindex of 58, co-authored 225 publications receiving 11143 citations. Previous affiliations of Z. Hong Zhou include University of Texas Health Science Center at Houston & University of Science and Technology of China.
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Journal ArticleDOI
A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
Wanwisa Dejnirattisai,Wiyada Wongwiwat,Sunpetchuda Supasa,Sunpetchuda Supasa,Xiaokang Zhang,Xiaokang Zhang,Xinghong Dai,Alexander Rouvinsky,Alexander Rouvinsky,Amonrat Jumnainsong,Amonrat Jumnainsong,Carolyn Edwards,Nguyen Than Ha Quyen,Thaneeya Duangchinda,Jonathan M. Grimes,Wen-Yang Tsai,Chih Yun Lai,Wei-Kung Wang,Prida Malasit,Prida Malasit,Jeremy Farrar,Cameron P. Simmons,Z. Hong Zhou,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +27 more
TL;DR: The results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
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A novel intracellular protein delivery platform based on single-protein nanocapsules
Ming Yan,Juanjuan Du,Zhen Gu,Min Liang,Yufang Hu,Wenjun Zhang,Saul J. Priceman,Lily Wu,Z. Hong Zhou,Zheng Liu,Tatiana Segura,Yi Tang,Yunfeng Lu +12 more
TL;DR: A novel delivery platform based on nanocapsules consisting of a protein core and a thin permeable polymeric shell that can be engineered to either degrade or remain stable at different pHs is shown, suggesting potential applications in imaging, therapy and cosmetics fields.
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Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks
Hongrong Liu,Hongrong Liu,Hongrong Liu,Lei Jin,Lei Jin,Sok Boon S. Koh,Ivo Atanasov,Stan Schein,Stan Schein,Lily Wu,Lily Wu,Z. Hong Zhou,Z. Hong Zhou +12 more
TL;DR: The structure of the whole human adenovirus virion is reported at 3.6 angstroms resolution by cryo–electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins, extensions of the major capsids, and interactions within three protein-protein networks.
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Cryo-EM structure of the mature dengue virus at 3.5-A resolution.
Xiaokang Zhang,Peng Ge,Peng Ge,Peng Ge,Xuekui Yu,Xuekui Yu,Xuekui Yu,Jennifer M Brannan,Jennifer M Brannan,Guo-Qiang Bi,Qinfen Zhang,Stan Schein,Stan Schein,Z. Hong Zhou +13 more
TL;DR: The atomic model of the whole virion from cryo–electron microscopy at 3.5-Å resolution reveals that in the mature virus at neutral extracellular pH, the N-terminal 20-amino-acid segment of M prevents spring-loaded E fusion protein from prematurely exposing its fusion peptide.
Journal ArticleDOI
Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism.
Huan Meng,Sui Yang,Zongxi Li,Tian Xia,Justin Chen,Zhaoxia Ji,Haiyuan Zhang,Xiang Wang,Sijie Lin,Connie Huang,Z. Hong Zhou,Jeffrey I. Zink,Andre E. Nel +12 more
TL;DR: Using a mesoporous silica nanoparticle library that has been constructed to cover a range of different lengths, it is demonstrated that the AR of rod-shaped particles determines the rate and abundance of MSNP uptake by a macropinocytosis process in HeLa and A549 cancer cell lines.