Z
Zohar Shipony
Researcher at Stanford University
Publications - 12
Citations - 1171
Zohar Shipony is an academic researcher from Stanford University. The author has contributed to research in topics: Chromatin & Transcription factor. The author has an hindex of 5, co-authored 12 publications receiving 569 citations. Previous affiliations of Zohar Shipony include Howard Hughes Medical Institute.
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Journal ArticleDOI
Chromatin accessibility and the regulatory epigenome.
TL;DR: The goal is to illustrate how chromatin accessibility defines regulatory elements within the genome and how these epigenetic features are dynamically established to control gene expression.
Journal ArticleDOI
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).
Maya Maor-Nof,Zohar Shipony,Rodrigo Lopez-Gonzalez,Lisa Nakayama,Yong Jie Zhang,Julien Couthouis,Jacob A. Blum,Patricia A. Castruita,Gabriel R. Linares,Kai Ruan,Gokul Ramaswami,David J. Simon,Aviv Nof,Manuel Santana,Kyuho Han,Nasa Sinnott-Armstrong,Michael C. Bassik,Daniel H. Geschwind,Marc Tessier-Lavigne,Laura D. Attardi,Thomas E. Lloyd,Justin K. Ichida,Fen-Biao Gao,William J. Greenleaf,Jennifer S. Yokoyama,Leonard Petrucelli,Aaron D. Gitler +26 more
TL;DR: The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene as mentioned in this paper.
Journal ArticleDOI
Long-range single-molecule mapping of chromatin accessibility in eukaryotes.
Zohar Shipony,Georgi K. Marinov,Matthew P. Swaffer,Nicholas A. Sinnott-Armstrong,Jan M. Skotheim,Anshul Kundaje,William J. Greenleaf +6 more
TL;DR: This strategy is based on combining the preferential methylation of open chromatin regions by DNA methyltransferases with low sequence specificity, in this case EcoGII, an N 6 -methyladenosine (m 6 A) methyltransferase, and the ability of nanopore sequencing to directly read DNA modifications.
Journal ArticleDOI
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.
Wendy Wenderski,Wendy Wenderski,Lu Wang,Lu Wang,Andrey Krokhotin,Andrey Krokhotin,Jessica J. Walsh,Hongjie Li,Hongjie Li,Hirotaka Shoji,Shereen G. Ghosh,Shereen G. Ghosh,Renee D. George,Renee D. George,Erik L. Miller,Erik L. Miller,Laura Elias,Laura Elias,Mark A. Gillespie,Esther Y. Son,Esther Y. Son,Brett T. Staahl,Brett T. Staahl,Seung Tae Baek,Seung Tae Baek,Valentina Stanley,Valentina Stanley,Cynthia Moncada,Cynthia Moncada,Zohar Shipony,Zohar Shipony,Sara B. Linker,Maria C. Marchetto,Fred H. Gage,Dillon Y. Chen,Dillon Y. Chen,Tipu Sultan,Maha S. Zaki,Jeffrey A. Ranish,Tsuyoshi Miyakawa,Liqun Luo,Liqun Luo,Robert C. Malenka,Gerald R. Crabtree,Gerald R. Crabtree,Joseph G. Gleeson,Joseph G. Gleeson +46 more
TL;DR: Surprisingly, mutation of Actl6b relieved repression of early response genes including AP1 transcription factors, increased chromatin accessibility at AP1 binding sites, and transcriptional changes in late response genes associated with early response transcription factor activity.
Journal ArticleDOI
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci.
Hamish W King,Kristen L. Wells,Kristen L. Wells,Zohar Shipony,Arwa Kathiria,Lisa E. Wagar,Lisa E. Wagar,Caleb A. Lareau,Caleb A. Lareau,Nara Orban,Robson Capasso,Mark M. Davis,Mark M. Davis,Lars M. Steinmetz,Louisa K. James,William J. Greenleaf +15 more
TL;DR: The germinal center (GC) response is critical for both effective adaptive immunity and establishing peripheral tolerance by limiting autoreactive B cells as discussed by the authors, and dysfunction in these processes can lead to...