Anhui Normal University

About: Anhui Normal University is a education organization based out in Wuhu, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 7955 authors who have published 7309 publications receiving 117443 citations.

Preparation of porous SnO2 microcubes and their enhanced gas-sensing property

Abstract: Porous SnO 2 microcubes were obtained through a facile chemical solution route with subsequent calcination and acid-washing process. Their structures and morphology evolution were comprehensively characterized via X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetric–differential thermal analysis, and Brunauer–Emmett–Teller N 2 adsorption–desorption analyses. The process of inducing porosity starts with a crystalline single-phase MnSn(OH) 6 precursor formed by the co-precipitation of the metal ions from the aqueous solution. Thermal decomposition of the precursors leads to an intimate mixture of Mn 3 O 4 and porous tetragonal SnO 2 . The SnO 2 microcubes are obtained after a hydrothermal acid-washing process. A decomposition–aggregation–dissolution process is proposed to demonstrate the formation of such special structure. Furthermore, the gas-sensing properties of the as-prepared porous SnO 2 microcubes were investigated in toxic volatile organic compounds, such as formaldehyde, ethanol, benzene, methanol, acetone, and toluene. The enhanced sensing performance of porous SnO 2 microcubes was demonstrated. The detection limits of formaldehyde and ethanol were approximately 0.09 and 0.12 ppm (signal-to-noise ratio, S / N = 3), respectively, which substantially benefitted from their unique porous structure and large surface area.

Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing.

Abstract: ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling cell fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency for editing genetic flow of mammalian cells, and for treating genetic disorders. The therapeutic potential of proteins with an intracellular target, however, is mostly challenged by their low cell impermeability. Therefore, a developing delivery system to transport protein to the site of action in a spatiotemporal controlled manner is of great importance to expand the therapeutic index of the protein.In this Account, we first summarize our most recent advances in designing combinatorial lipid nanoparticles with diverse chemical structures for intracellular protein delivery. By designing parallel Michael addition or ring-opening reaction of aliphatic amines, we have generated a combinatorial library of cationic lipids, and identified several leading nanoparticle ...