Institution
Cairo University
Education•Giza, Egypt•
About: Cairo University is a education organization based out in Giza, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 33532 authors who have published 55581 publications receiving 792654 citations. The organization is also known as: Fuad I University & King Fuad I University.
Topics: Population, Medicine, Cancer, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: A modified cuckoo search algorithm that imitates the obligate brood parasitic behavior of some cuckoos species in combination with the Lévy flight behavior and can significantly improve the classification performance is presented.
Abstract: In this paper, a modified cuckoo search algorithm with rough sets is presented to deal with high dimensionality data through feature selection. The modified cuckoo search algorithm imitates the obligate brood parasitic behavior of some cuckoo species in combination with the Levy flight behavior of some birds. The modified cuckoo search uses the rough sets theory to build the fitness function that takes the number of features in reduct set and the classification quality into account. The proposed algorithm is tested and validated benchmark on several benchmark datasets drawn from the UCI repository and using different evaluation criteria as well as a further analysis is carried out by means of the Analysis of Variance test. In addition, the proposed algorithm is experimentally compared with the existing algorithms on discrete datasets. Finally, two learning algorithms, namely K-nearest neighbors and support vector machines are used to evaluate the performance of the proposed approach. The results show that the proposed algorithm can significantly improve the classification performance.
154 citations
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Stony Brook University1, McGill University2, Rush University3, Cancer Care Ontario4, Sejong University5, Kuwait University6, Colorado School of Public Health7, National Research Council8, Health Canada9, Georgetown University Medical Center10, King George's Medical University11, Cairo University12, University of Florence13, Universiti Putra Malaysia14, University of Bologna15, Oregon State University16
TL;DR: The role that the innate immune cells of inflammatory responses play in tumorigenesis is reviewed and the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed.
Abstract: An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is despite the well-recognized role that innate and adaptive immunity play as essential factors in tumorigenesis. Here, we review the role that the innate immune cells of inflammatory responses play in tumorigenesis. Focus is placed on the molecules and pathways that have been mechanistically linked with tumor-associated inflammation. Within the context of chemically induced disturbances in immune function as co-factors in
154 citations
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TL;DR: CS nanocarriers developed in this study were able to contact intimately with the cornea providing slow gradual IM release with long-term drug level thereby increasing delivery to both external and internal ocular tissues.
Abstract: Two different chitosan (CS) nanocarriers namely nanoparticles and nanoemulsion were developed to prolong Indomethacin (IM) precorneal residence time and to improve its ocular bioavailability the main limitations in its management of post-operative inflammation and intraocular irritation after cataract extraction. CS-nanoparticles were developed by modified ionic gelation of CS with tripolyphosphate while nanoemulsion was prepared by spontaneous emulsification technique. Transmission electron microscopy revealed regular well-identified spherical shape. The nanoparticles had a mean size of 280 nm, a zeta potential of + 17 mV and high loading efficiency of 84.8 % while the mean size of nanoemulsion was affected by the nature of the surfactant used and varies between 220-690 nm. In vitro release studies, performed under sink conditions, revealed small initial burst release during the first hour followed by slow gradual drug release of 76 and 86% from nanoparticles and nanoemulsion respectively during a 24 h period. In vivo studies and histopathological examination revealed that eyes of rabbits treated with nanoemulsion showed clearer healing of corneal chemical ulcer with moderate effective inhibition of polymorph nuclear leukocytic infiltration (PMNLs) compared with nanoparticles preparation. Moreover, following topical instillation of CS-nanoemulsion to rabbits, it was possible to achieve therapeutic concentration of IM in the cornea through out the duration of the study and fairly high IM level in inner ocular structure, aqueous humor. These levels were significantly higher than those obtained following instillation of IM solution. Therefore, CS nanocarriers developed in this study were able to contact intimately with the cornea providing slow gradual IM release with long-term drug level thereby increasing delivery to both external and internal ocular tissues.
154 citations
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TL;DR: The study shed light to the problem of multi toxicants in a food commodity such as cucumber; a common element in the daily human diet.
154 citations
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TL;DR: In this paper, a study of the tribological properties of two locally developed polymeric composite materials for bearing applications is presented, based on a scanning electron microscope examination, which revealed that the reinforcement volume fraction as well as orientation have considerable effect on the friction and wear of polyester composites.
154 citations
Authors
Showing all 33886 results
Name | H-index | Papers | Citations |
---|---|---|---|
Chiara Mariotti | 141 | 1426 | 98157 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Andrea Giammanco | 135 | 1362 | 98093 |
Matthew Herndon | 133 | 1732 | 97466 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Pedro G Mercadante | 129 | 1331 | 86378 |
Alexander Nikitenko | 129 | 1159 | 82102 |
Stephen G. Ellis | 127 | 655 | 65073 |
Peter R. Carroll | 125 | 966 | 64032 |
Mikhail Dubinin | 125 | 1091 | 79808 |
Cesar Augusto Bernardes | 124 | 965 | 70889 |
K. Krajczar | 124 | 646 | 65885 |
Flavia De Almeida Dias | 120 | 590 | 59083 |
Jaap Goudsmit | 111 | 581 | 42149 |
Hans J. Eysenck | 106 | 512 | 59690 |