Institution
Cairo University
Education•Giza, Egypt•
About: Cairo University is a education organization based out in Giza, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 33532 authors who have published 55581 publications receiving 792654 citations. The organization is also known as: Fuad I University & King Fuad I University.
Topics: Population, Medicine, Cancer, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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University of Sydney1, Minia University2, Leipzig University3, St. Vincent's Health System4, The Chinese University of Hong Kong5, University of Nottingham6, University of Plymouth7, University of Turin8, Casa Sollievo della Sofferenza9, Nepean Hospital10, University of Bonn11, Cairo University12, Charité13, Fremantle Hospital14, Royal Perth Hospital15, University of Queensland16, University of New South Wales17, Westmead Hospital18, Newcastle University19, Princess Alexandra Hospital20
TL;DR: It is demonstrated that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner and is maximal in young females, especially those with HCV genotype 3.
Abstract: Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis.
149 citations
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TL;DR: In this paper, controlled crystallization of selected bioglasses to their corresponding bioglass-ceramics was carried out by using diloatometric measurement and differential thermal analysis (DTA).
148 citations
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TL;DR: The experimental result reveals that the proposed nature-inspired algorithm finds an optimal subset of features, maximizing the accuracy and minimizing a number of features selected and is more stable.
148 citations
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TL;DR: In this paper, the authors applied methodologies for rainfall-runoff and groundwater recharge computations that heavily rely on observations extracted from a wide-range of global remote sensing data sets (TRMM, SSM/I, Landsat TM, AVHRR, AMSR-E, and ASTER) using the arid Sinai Peninsula (SP) and the Eastern Desert (ED) as their test sites.
148 citations
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TL;DR: These findings implicate a defect in Wnt signaling in the cerebellar midline phenotype seen in Joubert syndrome that can be overcome with Wnt stimulation.
Abstract: The ciliopathy Joubert syndrome is marked by cerebellar vermis hypoplasia, a phenotype for which the pathogenic mechanism is unclear. To investigate Joubert syndrome pathogenesis, we have examined mice with mutated Ahi1, the first identified Joubert syndrome-associated gene. These mice show cerebellar hypoplasia with a vermis-midline fusion defect early in development. This defect is concomitant with expansion of the roof plate and is also evident in a mouse mutant for another Joubert syndrome-associated gene, Cep290. Furthermore, fetal magnetic resonance imaging (MRI) of human subjects with Joubert syndrome reveals a similar midline cleft, suggesting parallel pathogenic mechanisms. Previous evidence has suggested a role for Jouberin (Jbn), the protein encoded by Ahi1, in canonical Wnt signaling. Consistent with this, we found decreased Wnt reporter activity at the site of hemisphere fusion in the developing cerebellum of Ahi1-mutant mice. This decrease was accompanied by reduced proliferation at the site of fusion. Finally, treatment with lithium, a Wnt pathway agonist, partially rescued this phenotype. Our findings implicate a defect in Wnt signaling in the cerebellar midline phenotype seen in Joubert syndrome that can be overcome with Wnt stimulation.
148 citations
Authors
Showing all 33886 results
Name | H-index | Papers | Citations |
---|---|---|---|
Chiara Mariotti | 141 | 1426 | 98157 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Andrea Giammanco | 135 | 1362 | 98093 |
Matthew Herndon | 133 | 1732 | 97466 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Pedro G Mercadante | 129 | 1331 | 86378 |
Alexander Nikitenko | 129 | 1159 | 82102 |
Stephen G. Ellis | 127 | 655 | 65073 |
Peter R. Carroll | 125 | 966 | 64032 |
Mikhail Dubinin | 125 | 1091 | 79808 |
Cesar Augusto Bernardes | 124 | 965 | 70889 |
K. Krajczar | 124 | 646 | 65885 |
Flavia De Almeida Dias | 120 | 590 | 59083 |
Jaap Goudsmit | 111 | 581 | 42149 |
Hans J. Eysenck | 106 | 512 | 59690 |