Institution
Cairo University
Education•Giza, Egypt•
About: Cairo University is a education organization based out in Giza, Egypt. It is known for research contribution in the topics: Population & Medicine. The organization has 33532 authors who have published 55581 publications receiving 792654 citations. The organization is also known as: Fuad I University & King Fuad I University.
Topics: Population, Medicine, Cancer, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: RNF138 is identified as a ubiquitin E3 ligase that regulates the HR pathway and stimulates DNA end resection and promotes ATR-dependent signalling and DSB repair by HR, thereby contributing to cell survival on exposure to DSB-inducing agents.
Abstract: DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining or homologous recombination (HR). Cell cycle stage and DNA end resection are believed to regulate the commitment to HR repair. Here we identify RNF138 as a ubiquitin E3 ligase that regulates the HR pathway. RNF138 is recruited to DNA damage sites through zinc fingers that have a strong preference for DNA with 5′- or 3′-single-stranded overhangs. RNF138 stimulates DNA end resection and promotes ATR-dependent signalling and DSB repair by HR, thereby contributing to cell survival on exposure to DSB-inducing agents. Finally, we establish that RNF138-dependent Ku removal from DNA breaks is one mechanism whereby RNF138 can promote HR. These results establish RNF138 as an important regulator of DSB repair pathway choice. Jackson and colleagues and Hendzel and colleagues reveal that the E3 ligase RNF138 functions in the repair of double-strand breaks by promoting CtIP accumulation and displacement of DNA-PK subunit Ku.
119 citations
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National Guard Health Affairs1, King Saud bin Abdulaziz University for Health Sciences2, Emory University3, Alfaisal University4, United Kingdom Ministry of Defence5, King Khalid University6, King Saud Medical City7, Tanta University8, University of Toronto9, Sunnybrook Health Sciences Centre10, University of Virginia11, Cairo University12
TL;DR: The aim of this article is to describe the statistical analysis plan for the MIRACLE trial, which is the first randomized controlled trial for MERS treatment, and the primary outcome is 90-day mortality.
Abstract: The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. The MIRACLE trial is designed as a recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The aim of this article is to describe the statistical analysis plan for the MIRACLE trial. The primary outcome is 90-day mortality. The primary analysis will follow the intention-to-treat principle. The MIRACLE trial is the first randomized controlled trial for MERS treatment. ClinicalTrials.gov, NCT02845843. Registered on 27 July 2016.
119 citations
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TL;DR: A comparative in vivo and in vitro study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.
119 citations
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TL;DR: In this paper, a novel biorenewable, waterborne, castor oil-based polyurethane dispersions (PUDs) were successfully synthesized via homogeneous solution polymerization in methyl ethyl ketone followed by solvent exchange with water.
Abstract: Novel biorenewable, waterborne, castor oil-based polyurethane dispersions (PUDs) were successfully synthesized via homogeneous solution polymerization in methyl ethyl ketone followed by solvent exchange with water. Small-amplitude oscillatory shear flow experiments were used to systematically investigate the rheological behavior of these environmentally friendly, biorenewable, aqueous dispersions as a function of angular frequency, solid content, and temperature. In addition, the morphology of the dispersions was investigated at 60 °C for different time intervals using transmission electron microscopy (TEM). The solid content and temperature were found to significantly affect the rheological behavior of the PUDs. The composition dependency of the complex viscosity (η*) was found to be well described by the Krieger–Dougherty equation. Thermally induced gelation was observed for PUDs with a solid content ≥27 wt %. Although the viscoelastic behavior of the PUDs was well described by the time–temperature supe...
119 citations
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TL;DR: The results suggest that autologous CD34+ stem cell transplantation may be safely administered and appears to offer some therapeutic benefit to patients with both viral and autoimmune-induced end-stage liver disease.
119 citations
Authors
Showing all 33886 results
Name | H-index | Papers | Citations |
---|---|---|---|
Chiara Mariotti | 141 | 1426 | 98157 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Andrea Giammanco | 135 | 1362 | 98093 |
Matthew Herndon | 133 | 1732 | 97466 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Pedro G Mercadante | 129 | 1331 | 86378 |
Alexander Nikitenko | 129 | 1159 | 82102 |
Stephen G. Ellis | 127 | 655 | 65073 |
Peter R. Carroll | 125 | 966 | 64032 |
Mikhail Dubinin | 125 | 1091 | 79808 |
Cesar Augusto Bernardes | 124 | 965 | 70889 |
K. Krajczar | 124 | 646 | 65885 |
Flavia De Almeida Dias | 120 | 590 | 59083 |
Jaap Goudsmit | 111 | 581 | 42149 |
Hans J. Eysenck | 106 | 512 | 59690 |