Institution
Cornell University
Education•Ithaca, New York, United States•
About: Cornell University is a education organization based out in Ithaca, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 102246 authors who have published 235546 publications receiving 12283673 citations. The organization is also known as: Cornell & CUI.
Topics: Population, Gene, Cancer, Context (language use), Medicine
Papers published on a yearly basis
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Stanford University1, Prescott College2, University of Illinois at Urbana–Champaign3, Cornell University4, National Center for Atmospheric Research5, University of Bristol6, University of São Paulo7, Columbia University8, Michigan State University9, University of Colorado Boulder10, China Agricultural University11
TL;DR: Solutions to the nutrient challenges that face global agriculture can be informed by analyses of trajectories of change within, as well as across, agricultural systems.
Abstract: Nutrient cycles link agricultural systems to their societies and surroundings; inputs of nitrogen and phosphorus in particular are essential for high crop yields, but downstream and downwind losses of these same nutrients diminish environmental quality and human well-being. Agricultural nutrient balances differ substantially with economic development, from inputs that are inadequate to maintain soil fertility in parts of many developing countries, particularly those of sub-Saharan Africa, to excessive and environmentally damaging surpluses in many developed and rapidly growing economies. National and/or regional policies contribute to patterns of nutrient use and their environmental consequences in all of these situations ( 1 ). Solutions to the nutrient challenges that face global agriculture can be informed by analyses of trajectories of change within, as well as across, agricultural systems.
1,150 citations
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TL;DR: In a laboratory assay, it is found that larvae of the monarch butterfly, Danaus plexippus, reared on milkweed leaves dusted with pollen from Bt corn, ate less, grew more slowly and suffered higher mortality than larvae rearing on leaves dusting with untransformed corn pollen or on leaves without pollen.
Abstract: Although plants transformed with genetic material from the bacterium Bacillus thuringiensis (Bt ) are generally thought to have negligible impact on non-target organisms1, Bt corn plants might represent a risk because most hybrids express the Bt toxin in pollen2, and corn pollen is dispersed over at least 60 metres by wind3. Corn pollen is deposited on other plants near corn fields and can be ingested by the non-target organisms that consume these plants. In a laboratory assay we found that larvae of the monarch butterfly, Danaus plexippus, reared on milkweed leaves dusted with pollen from Bt corn, ate less, grew more slowly and suffered higher mortality than larvae reared on leaves dusted with untransformed corn pollen or on leaves without pollen.
1,148 citations
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TL;DR: Once-daily oral daclatasvir plus sofosbuvir was associated with high rates of sustained virologic response among patients infected with HCV genotype 1, 2, or 3, including patients with no response to prior therapy with telaprevir or boceprevir.
Abstract: Background All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated daclatasvir (an HCV NS5A replication complex inhibitor) plus sofosbuvir (a nucleotide analogue HCV NS5B polymerase inhibitor) in patients infected with HCV genotype 1, 2, or 3. Methods In this open-label study, we initially randomly assigned 44 previously untreated patients with HCV genotype 1 infection and 44 patients infected with HCV genotype 2 or 3 to daclatasvir at a dose of 60 mg orally once daily plus sofosbuvir at a dose of 400 mg orally once daily, with or without ribavirin, for 24 weeks. The study was expanded to include 123 additional patients with genotype 1 infection who were randomly assigned to daclatasvir plus sofosbuvir, with or without ribavirin, for 12 weeks (82 previously untreated patients) or 24 weeks (41 patients who had previous virologic failure with telaprevir or boceprevir plus peginterferon alfa–ribavirin). The primary end point was a sustained virologi...
1,148 citations
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TL;DR: Broad, quantitative support is reported for two long-standing hypotheses that explain why only some naturalized species have large impacts against native species, and indicates that invasive plants' impacts may be a function of both release from and accumulation of natural enemies, including pathogens.
Abstract: Invasive plant species both threaten native biodiversity and are economically costly, but only a few naturalized species become pests. Here we report broad, quantitative support for two long-standing hypotheses that explain why only some naturalized species have large impacts. The enemy release hypothesis argues that invaders' impacts result from reduced natural enemy attack. The biotic resistance hypothesis argues that interactions with native species, including natural enemies, limit invaders' impacts. We tested these hypotheses for viruses and for rust, smut and powdery mildew fungi that infect 473 plant species naturalized to the United States from Europe. On average, 84% fewer fungi and 24% fewer virus species infect each plant species in its naturalized range than in its native range. In addition, invasive plant species that are more completely released from pathogens are more widely reported as harmful invaders of both agricultural and natural ecosystems. Together, these results strongly support the enemy release hypothesis. Among noxious agricultural weeds, species accumulating more pathogens in their naturalized range are less widely noxious, supporting the biotic resistance hypothesis. Our results indicate that invasive plants' impacts may be a function of both release from and accumulation of natural enemies, including pathogens.
1,148 citations
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TL;DR: It is shown that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns, and it is demonstrated that cellular origin influences the in vitro differentiation potentials of iPSC into embryoid bodies and different hematopsic cell types.
Abstract: Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages.
1,147 citations
Authors
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Name | H-index | Papers | Citations |
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Eric S. Lander | 301 | 826 | 525976 |
David Miller | 203 | 2573 | 204840 |
Lewis C. Cantley | 196 | 748 | 169037 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Scott M. Grundy | 187 | 841 | 231821 |
Paul G. Richardson | 183 | 1533 | 155912 |
Chris Sander | 178 | 713 | 233287 |
David R. Williams | 178 | 2034 | 138789 |
David L. Kaplan | 177 | 1944 | 146082 |
Kari Alitalo | 174 | 817 | 114231 |
Richard K. Wilson | 173 | 463 | 260000 |
George F. Koob | 171 | 935 | 112521 |
Avshalom Caspi | 170 | 524 | 113583 |
Derek R. Lovley | 168 | 582 | 95315 |
Stephen B. Baylin | 168 | 548 | 188934 |