Institution
Cornell University
Education•Ithaca, New York, United States•
About: Cornell University is a education organization based out in Ithaca, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 102246 authors who have published 235546 publications receiving 12283673 citations. The organization is also known as: Cornell & CUI.
Topics: Population, Gene, Cancer, Context (language use), Medicine
Papers published on a yearly basis
Papers
More filters
Aix-Marseille University1, Cornell University2, Washington University in St. Louis3, Charité4, Pasteur Institute5, French Institute of Health and Medical Research6, Keio University7, University of California, San Francisco8, Laboratory of Molecular Biology9, VU University Amsterdam10, University of Oxford11, University of Amsterdam12
TL;DR: The advances in ILC biology over the past decade are distill the advances to refine the nomenclature of ILCs and highlight the importance of I LCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration.
1,252 citations
Brown University1, Virginia Commonwealth University2, Stony Brook University3, Stanford University4, University of Washington5, University of Arizona6, Cornell University7, Emory University8, University of Texas Medical Branch9, University of Pittsburgh10, University of Texas Southwestern Medical Center11, Rush University Medical Center12
TL;DR: Although about half of patients with chronic forms of major depression have a response to short-term treatment with either nefazodone or a cognitive behavioral-analysis system of psychotherapy, the combination of the two is significantly more efficacious than either treatment alone.
Abstract: Background Patients with chronic forms of major depression are difficult to treat, and the relative efficacy of medications and psychotherapy is uncertain. Methods We randomly assigned 681 adults with a chronic nonpsychotic major depressive disorder to 12 weeks of outpatient treatment with nefazodone (maximal dose, 600 mg per day), the cognitive behavioral-analysis system of psychotherapy (16 to 20 sessions), or both. At base line, all patients had scores of at least 20 on the 24-item Hamilton Rating Scale for Depression (indicating clinically significant depression). Remission was defined as a score of 8 or less at weeks 10 and 12. For patients who did not have remission, a satisfactory response was defined as a reduction in the score by at least 50 percent from base line and a score of 15 or less. Raters were unaware of the patients' treatment assignments. Results Of the 681 patients, 662 attended at least one treatment session and were included in the analysis of response. The overall rate of response ...
1,251 citations
TL;DR: The findings position the Ras/MAPK pathway upstream of the TSC complex and suggest that Erk may modulate mTOR signaling and contribute to disease progression through phosphorylation and inactivation of TSC2.
1,250 citations
TL;DR: High resolution structures for the complexes formed by the immunosuppressive agents FK506 and rapamycin with the human immunophilin FKBP-12 have been determined by X-ray diffraction and suggest ways in which this catalytic activity could operate.
1,249 citations
Stephen Richards1, Richard A. Gibbs1, George M. Weinstock1, Susan J. Brown2 +187 more•Institutions (47)
TL;DR: Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products.
Abstract: Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
1,248 citations
Authors
Showing all 103081 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric S. Lander | 301 | 826 | 525976 |
| David Miller | 203 | 2573 | 204840 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Charles A. Dinarello | 190 | 1058 | 139668 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Paul G. Richardson | 183 | 1533 | 155912 |
| Chris Sander | 178 | 713 | 233287 |
| David R. Williams | 178 | 2034 | 138789 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Kari Alitalo | 174 | 817 | 114231 |
| Richard K. Wilson | 173 | 463 | 260000 |
| George F. Koob | 171 | 935 | 112521 |
| Avshalom Caspi | 170 | 524 | 113583 |
| Derek R. Lovley | 168 | 582 | 95315 |
| Stephen B. Baylin | 168 | 548 | 188934 |