Geelong Football Club

About: Geelong Football Club is a based out in . It is known for research contribution in the topics: Population & Wool. The organization has 1503 authors who have published 1826 publications receiving 34162 citations. The organization is also known as: Geelong Cats.

Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

Abstract: An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.

Australian equine influenza: vaccine protection in the UK.

Abstract: SIR,— During 2007, major outbreaks of equine influenza occurred in Asia and Australia, affecting more than 100,000 horses. These outbreaks were caused by h3n8 equine influenza viruses (eivs) of the American lineage. The majority of the recreational horse populations in Australia, Kazakhstan,

Electrophysiological evidence of RML12 mosquito cell line towards neuronal differentiation by 20-hydroxyecdysdone.

Abstract: Continuous cell lines from insect larval tissues are widely used in different research domains, such as virology, insect immunity, gene expression, and bio pharmacology. Previous study showed that introduction of 20-hydroxyecdysone to Spodoptera cell line induced a neuron-like morphology with neurite extensions. Despite some results suggesting potential presence of neuro-receptors, no study so far has shown that these neuron-induced cells were functional. Here, using microelectrode arrays, we showed that the mosquito cell line, RML12, differentiated with 20-hydroxyecdysone, displays spontaneous electrophysiological activity. Results showed that these cells can be stimulated by GABAergic antagonist as well as nicotinic agonist. These results provide new evidence of neuron-like functionality of 20-hydroxyecdysone induced differentiated mosquito cell line. Finally, we used this new model to test the effects of two insecticides, temephos and permethrin. Our analysis revealed significant changes in the spiking activity after the introduction of these insecticides with prolonged effect on the neuronal activity. We believe that this differentiated mosquito neuronal cell model can be used for high-throughput screening of new pesticides on insect nervous system instead of primary neurons or in vivo studies.

The Wisheart affair: responses to Dunn.

Abstract: # The Bristol cardiac disaster {#article-title-2} I wish to express my disappointment and concern at the publication of Peter Dunn's article.1 The article raises several important points, which need to be addressed, and I feel that my knowledge and position in Bristol at the time give me some authority to comment. Dunn asks, “Why were the surgeons judged only on a small selected fraction (4%) of their paediatric surgical workload during 1990-5?” I find his answer less satisfactory than the alternative explanation that the United Bristol Healthcare Trust only provided to the GMC's disciplinary committee the details of the operations that it had requested at such short notice that the GMC was unable to deal with anything other than the operations for atrioventricular canal and arterial switch. Even in these limited cases the excess mortality for these two operations was sufficient for the disciplinary committee to reach its verdict. However, we now learn that there were other operations with equally bad records for mortality. On 27 …

Necrotising arachnidism treated with hyperbaric oxygen.

Abstract: required painful daily dressing changes, made tolerable through the use a 50:50 mixture of nitrous oxide and oxygen which he inhaled through a mask. Over seven months the patient was exposed daily to this gas and underwent multiple administrations of nitrous oxide general anaesthesia for prolonged orthopaedic procedures. After the last operation, which lasted four hours, the patient developed intermittent drowsiness and confusion that was exacerbated by further use of the nitrous oxide/oxygen gas. He complained of paraesthesiae in the legs, an \"electric shock\" sensation with flexion of the neck (Lhermitte's sign) and he was unable to stand unassisted. Examination revealed generalised hyperreflexia, increased tone in the lower limbs and extensor plantar responses, bilateral foot drop and weakness of the intrinsic hand muscles, and distal reduction of proprioception and vibration sense signs of myeloneuropathy indistinguishable from classical subacute combined degeneration of the cord due to vitamin BI2 deficiency. Preoperative haematological test results were normal but postoperative results showed leucopenia at 1.1 X 109/L (normal range, 4.0-10.5 x 109/L) and severe neutropenia at 0.1 x 10 9/L (normal range, 1.9-6.8 X 109/L). Serum and red cell folate levels were normal, but his vitamin BI 2 level was < 40 pmollL (normal range, 130660 pmol/L) and his bone marrow showed megaloblastic changes. There was no evidence of dietary deficiency of vitamin BI2 or of malabsorption. Pernicious anaemia was excluded by the absence of intrinsic factor antibodies and a subsequent Schilling test was normal. Nerve conduction studies revealed absent sensory and motor potentials in the lower limbs and normal values in the upper limbs. Needle electromyogram revealed profuse denervation potentials in muscles below the knees. Computed tomography showed widened cerebral sulci and enlarged ventricles. Magnetic resonance imaging showed an abnormal signal within the spinal cord. The neurological and haematological findings were attributed to vitamin BI 2 deficiency induced by chronic exposure to nitrous oxide. Use of the nitrous oxide/oxygen gas was stopped and daily replacement of vitamin BI 2 was commenced. The patient's encephalopathy cleared within 10 days and there was steady improvement in his general neurological status. Twelve months later, all neurological abnormalities had resolved and a repeat brain computed tomography scan was normal. Normal haematological and vitamin BI 2 results have been reported in published cases of nitrous oxide neurctoxicity-\" and therefore do not exclude the diagnosis. Clinicians should be aware of the potential danger of repeated exposure to nitrous oxide in hospitalised patients.