ICM Partners

About: ICM Partners is a based out in . It is known for research contribution in the topics: Population & Breast cancer. The organization has 1311 authors who have published 1521 publications receiving 33745 citations. The organization is also known as: International Creative Management Partners.

The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.

Abstract: Purpose of reviewThis study, taking the example of Alzheimer's and Parkinson's diseases, presents the experimental and human data that support the hypothesis that Aβ, tau, and α-synuclein may seed and propagate the pathology and consider the potential clinical consequences.Recent findingsAβ aggregat

Reynolds-averaged modeling of turbulent flows of power-law fluids

Abstract: The paper presents a novel Reynolds-averaged turbulence model for flows of power-law fluid. The model uses the elliptic relaxation approach to capture the near-wall turbulence anisotropy. The turbulence model for Newtonians fluids is modified by introducing closed approximations of correlations between velocity and viscosity fluctuations. The approximation for non-Newtonian extra stress is derived with the assumption of smallness of molecular viscosity fluctuations. A closed model for the averaged molecular viscosity is derived which takes into account its nonlinear dependence on the shear rate. Validation of the model against the direct numerical simulation (DNS) data for power-law fluids flows in the pipe demonstrates that new model is able to predict the main features of the non-Newtonian turbulence. Mean velocity, turbulent energy and averaged molecular viscosity distributions agree well with DNS data.

Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer.

Abstract: Interpretation of variants of unknown significance (VUS) is a major challenge for laboratories performing molecular diagnosis of hereditary breast and ovarian cancer (HBOC), especially considering that many genes are now known to be involved in this syndrome. One important way these VUS can have a functional impact is through their effects on RNA splicing. Here we present a custom RNA-Seq assay plus bioinformatics and biostatistics pipeline to analyse specifically alternative and abnormal splicing junctions in 11 targeted HBOC genes. Our pipeline identified 14 new alternative splices in BRCA1 and BRCA2 in addition to detecting the majority of known alternative spliced transcripts therein. We provide here the first global splicing pattern analysis for the other nine genes, which will enable a comprehensive interpretation of splicing defects caused by VUS in HBOC. Previously known splicing alterations were consistently detected, occasionally with a more complex splicing pattern than expected. We also found that splicing in the 11 genes is similar in blood and breast tissue, supporting the utility and simplicity of blood splicing assays. Our pipeline is ready to be integrated into standard molecular diagnosis for HBOC, but it could equally be adapted for an integrative analysis of any multigene disorder.

Tackling the social cognition paradox through multi-scale approaches.

Abstract: Recent debates regarding the primacy of social interaction versus individual cognition appear to be caused by the lack of an integrative account of the multiple scales at play. We suggest that reconciling individual autonomy and dyadic interactive viewpoints requires the taking into account of different time scales (e.g., development, learning) and levels of organization (e.g., genetic, neural, behavioral, social). We argue that this challenge requires the joint development of tools for two-body and second person neuroscience, along with the theoretical concepts and methods of coordination dynamics and systems biology. Such a research program may be particularly fruitful in deciphering complex socio-developmental diseases that are known to involve alterations on multiple levels.

Impairment of a parieto-premotor network specialized for handwriting in writer's cramp

Abstract: Handwriting with the dominant hand is a highly skilled task singularly acquired in humans. This skill is the isolated deficit in patients with writer's cramp (WC), a form of dystonia with maladaptive plasticity, acquired through intensive and repetitive motor practice. When a skill is highly trained, a motor program is created in the brain to execute the same movement kinematics regardless of the effector used for the task. The task- and effector-specific symptoms in WC suggest that a problem particularly occurs in the brain when the writing motor program is carried out by the dominant hand. In this MRI study involving 12 WC patients (with symptoms only affecting the right dominant hand during writing) and 15 age matched unaffected controls we showed that: (1) the writing program recruited the same network regardless of the effector used to write in both groups; (2) dominant handwriting recruited a segregated parieto-premotor network only in the control group; (3) local structural alteration of the premotor area, the motor component of this network, predicted functional connectivity deficits during dominant handwriting and symptom duration in the patient group. Dysfunctions and structural abnormalities of a segregated parieto-premotor network in WC patients suggest that network specialization in focal brain areas is crucial for well-learned motor skill.