ICM Partners

About: ICM Partners is a based out in . It is known for research contribution in the topics: Population & Breast cancer. The organization has 1311 authors who have published 1521 publications receiving 33745 citations. The organization is also known as: International Creative Management Partners.

Performance of stabilized adobe blocks prepared using construction and demolition waste

Abstract: This paper presents an experimental investigation into product based research, in preparation of stabilized adobe blocks (SAB) by attempting to utilize construction and demolition waste (CDW) in the form of excavated natural soil (NS) and crushed demolished brick masonry. SAB are energy efficient sustainable variety of masonry units. A detailed study on strength, durability and elastic properties of SAB produced in different combinations were carried out, to determine the optimum combination and gradation, to achieve the required engineering properties. The experimental results were evidenced at a micro-level through microstructure analysis using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). When excavated natural soil was replaced in the order of 60–80% by crushed demolition brick masonry waste, the test results indicated better strength and durability characteristics. The experimental program indicates suitability and potential of utilizing crushed demolished brick masonry waste as partial replacement to excavated natural soil in preparation of stabilized adobe blocks. This attempt of experimental research studying performance of masonry units is one of the ways to address the disposal of construction and demolition waste.

Prostatitis, other genitourinary infections and prostate cancer risk: Influence of non-steroidal anti-inflammatory drugs? Results from the EPICAP study.

Abstract: Epidemiological studies have suggested that prostatitis may increase the risk of prostate cancer due to chronic inflammation. We studied the association between several genitourinary infections and the risk of prostate cancer based on data from the EPICAP study. EPICAP is a population-based case-control study conducted in the departement of Herault, France, between 2012 and 2014. A total of 819 incident cases and 879 controls have been face to face interviewed using a standardized questionnaire gathering information on known or suspected risk factors of prostate cancer, and personal history of genitourinary infections: prostatitis, urethritis, orchi-epididymitis, and acute pyelonephritis. Odds Ratios (OR) and their 95% confidence interval were estimated using multivariate unconditional logistic regression. Overall, 139 (18%) cases and 98 (12%) controls reported having at least one personal history of genitourinary infections (OR = 1.64 [1.23-2.20]). The risk increased with the number of infections (p-trend < 0.05). The association was specifically observed with personal history of chronic prostatitis and acute pyelonephritis (OR = 2.95 [1.26-6.92] and OR = 2.66 [1.29-5.51], respectively) and in men who did not use any non-steroidal anti-inflammatory drugs (OR = 2.00 [1.37-2.91]). Our results reinforce the hypothesis that chronic inflammation, generated by a personal history of genitourinary infections, may play a role in prostate carcinogenesis.

Deep structural brain lesions associated with consciousness impairment early after hemorrhagic stroke

Abstract: The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtained within the first week of the bleed and command following throughout the ICU stay. A machine learning approach was applied to identify MRI findings that best predicted the level consciousness. From 158 intracerebral hemorrhage patients that underwent MRI, one third was unconscious at the time of MRI and half of these patients recovered consciousness by ICU discharge. Deep structural lesions predicted both, impairment and recovery of consciousness, together with established measures of mass effect. Lesions in the midbrain peduncle and pontine tegmentum alongside the caudate nucleus were implicated as critical structures. Unconscious patients predicted to recover consciousness by ICU discharge had better long-term functional outcomes than those predicted to remain unconscious.

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Abstract: In the Methods section of this Article, ‘greater than’ should have been ‘less than’ in the sentence ‘Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. ’. The Article has not been corrected.

NMR Delineation of Inner and Outer Protons from Paramagnetic Relaxation Perturbations in 1D and 2D Spectra of Peptides

Abstract: The use of soluble spin labels to filter out the cross-peaks of outer proton nuclei in 2D NMR spectra is proposed as a general method of obtaining structural information about complex molecules. Gramicidin S, a decapeptide of well defined and stable structure, has been used as a model system to correlate the paramagnetic effects observed in 1 D and 2D spectra and the peptide solution conformation. The method appears particularly suited to obtaining information about the hydrogen bonding of backbone amide protons.