Institution
ICM Partners
About: ICM Partners is a based out in . It is known for research contribution in the topics: Population & Breast cancer. The organization has 1311 authors who have published 1521 publications receiving 33745 citations. The organization is also known as: International Creative Management Partners.
Topics: Population, Breast cancer, Cancer, Cognition, Radiation therapy
Papers published on a yearly basis
Papers
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TL;DR: A novel mechanism of alternative splicing deregulation that may play a role in various other diseases with nuclear inclusions or foci containing an RNA binding protein is reported.
Abstract: A short abnormal polyalanine expansion in the polyadenylate-binding protein nuclear-1 (PABPN1) protein causes oculopharyngeal muscular dystrophy (OPMD). Mutated PABPN1 proteins accumulate as insoluble intranuclear aggregates in muscles of OPMD patients. While the roles of PABPN1 in nuclear polyadenylation and regulation of alternative poly(A) site choice have been established, the molecular mechanisms which trigger pathological defects in OPMD and the role of aggregates remain to be determined. Using exon array, for the first time we have identified several splicing defects in OPMD. In particular, we have demonstrated a defect in the splicing regulation of the muscle-specific Troponin T3 (TNNT3) mutually exclusive exons 16 and 17 in OPMD samples compared to controls. This splicing defect is directly linked to the SC35 (SRSF2) splicing factor and to the presence of nuclear aggregates. As reported here, PABPN1 aggregates are able to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35-mediated splicing. This results in a decreased calcium sensitivity of muscle fibers, which could in turn plays a role in muscle pathology. We thus report a novel mechanism of alternative splicing deregulation that may play a role in various other diseases with nuclear inclusions or foci containing an RNA binding protein.
27 citations
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TL;DR: In this article, thermal treatment, PDMS coating, and combined thermal treatment with PDMS methods were applied over NH2-MIL-53(Al)/cellulose acetate (CA) hollow fiber mixed matrix membranes (HFMMM) for CO2/CH4 and CO 2/N2 separation.
Abstract: In the current work, thermal treatment, PDMS coating, and combined thermal treatment with PDMS coating methods were applied over NH2-MIL-53(Al)/cellulose acetate (CA) hollow fiber mixed matrix membranes (HFMMM) for CO2/CH4 and CO2/N2 separation. The results showed that upon thermal treatment at 170 °C, CO2/CH4 and CO2/N2 gas pair selectivities of HFMMM were improved from 9.1 to 9.9 and 7.7 to 8.4, respectively. On the other hand, CO2/CH4 and CO2/N2 gas pair selectivities of HFMMMs were improved from 9.1 to 14.1 and 7.7 to 12.0, respectively, after thermal treatment at 220 °C. Substantial increment in gas pair selectivities of the thermally treated fibers was mainly due to polymer densification, which condensed the voids between polymer and particles. Subsequently, PDMS-coated HFMMMs exhibited gas pair selectivities of 17.0 and 16.2, respectively, which were higher compared to the untreated and thermally treated HFMMM. Highest improvement of CO2/CH4 and CO2/N2 gas pair selectivities were found for combined...
27 citations
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05 Dec 2014TL;DR: In this paper, a user interface of a controller has multiple touch-sensitive input transducers, e.g., capacitive pads, which are dynamically indicated: when any given touch sensitive input device is needed for input at a given step of the programming operation, an associated light source illuminates that input device so it is visible to the user.
Abstract: A user interface of a controller has multiple touch-sensitive input transducers, e.g., capacitive pads. The pads are dynamically indicated: When any given touch sensitive input device is needed for input at a given step of the programming operation, an associated light source illuminates that input device so it is visible to the user. Those touch-panel input devices not needed for that are left unilluminated, and the microprocessor ignores any input from those input devices. At each step of the operation or programming of the controller, only those input transducers for the inputs that are permitted or relevant to that state are indicated. Correspondingly, only the inputs that are generated by actuating the input transducers for the valid (i.e., permitted or relevant) inputs results in a change in the state of the program in the microprocessor.
27 citations
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Erasmus University Medical Center1, Western General Hospital2, University of Western Australia3, ICM Partners4, Academy for Urban School Leadership5, Heidelberg University6, Katholieke Universiteit Leuven7, Cliniques Universitaires Saint-Luc8, Princess Margaret Cancer Centre9, Royal North Shore Hospital10, University of Zurich11, Erasmus University Rotterdam12, European Organisation for Research and Treatment of Cancer13
TL;DR: In this paper, the 1st interim analysis of the CATNON trial showed benefit from adjuvant (adj) temozolomide (TMZ) on overall survival (OS) but remained inconclusive about concurrent (conc) TMZ.
Abstract: 2000Background: The 1st interim analysis of the CATNON trial showed benefit from adjuvant (adj) temozolomide (TMZ) on overall survival (OS) but remained inconclusive about concurrent (conc) TMZ. A ...
27 citations
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TL;DR: The results from a retrospective series of 41 cases are reported, including the identification of a new family with a CTNNA1 mutation and the first prophylactic total gastrectomy in an asymptomatic carrier after a normal upper endoscopy.
Abstract: In 2017, we implemented CTNNA1 germline analysis in probands suspected of having hereditary diffuse gastric cancer. Here, we report the results from a retrospective series of 41 cases, including the identification of a new family with a CTNNA1 mutation and the first prophylactic total gastrectomy in an asymptomatic carrier after a normal upper endoscopy. Diffuse gastric cancer foci with loss of catenin alpha-1 expression were seen in the resected tissue, suggesting that CTNNA1 and CDH1 germline mutations behave in a similar manner. Life-changing prophylactic total gastrectomy should therefore also be considered in CTNNA1 mutation carriers.
27 citations
Authors
Showing all 1311 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alexis Brice | 135 | 870 | 83466 |
Bruno Dubois | 124 | 646 | 78784 |
Harald Hampel | 109 | 601 | 65160 |
Alexandra Durr | 104 | 594 | 47018 |
Laurent D. Cohen | 94 | 417 | 42709 |
Jürgen Eckert | 92 | 1368 | 42119 |
Stéphane Lehéricy | 89 | 332 | 27214 |
Antoine Danchin | 80 | 483 | 30219 |
Marie Vidailhet | 79 | 391 | 21836 |
Josep M. Gasol | 77 | 313 | 22638 |
Mélanie Boly | 76 | 232 | 21552 |
Etienne C. Hirsch | 75 | 218 | 22591 |
Måns Ehrenberg | 74 | 234 | 17637 |
Elizabeth M. C. Fisher | 74 | 298 | 21150 |
Isabelle Arnulf | 73 | 331 | 18456 |