Institut de veille sanitaire

About: Institut de veille sanitaire is a healthcare organization based out in Saint-Maurice, France. It is known for research contribution in the topics: Population & Public health. The organization has 1055 authors who have published 1547 publications receiving 56945 citations. The organization is also known as: INVS & InVS.

Prospects for the BCG vaccination programme in France.

Abstract: Until recently, the French BCG vaccination programme consisted of a mandatory BCG vaccination before children started at daycare centres, and of re-vaccination of tuberculin-negative children. A re-assessment of this programme has been undertaken in recent years. It has led in 2004 to the discontinuation of all revaccinations and post-vaccination tuberculin tests except those post-vaccination tuberculin tests performed as part of a diagnosis of tuberculosis infection or disease or of the follow-up of health or social workers for whom BCG vaccination remains mandatory. Based on an estimate of the epidemiological impact of either selective vaccination of high risk children or discontinuation of BCG vaccination, and taking into account the risk-benefit balance that can be made of the two options, the Conseil Superieur d'Hygiene Publique de France (CSHPF, national high committee of public hygiene) has recommended a change to selective vaccination. However, the committee has proposed the strengthening of other control measures aimed at decreasing the risk of infection for children, as a pre-requisite to the implementation of this strategy. This position is made more complex by the withdrawal of the multipuncture technique in early 2006, previously used in France in more than 90% of BCG primary vaccinations.

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults.

Abstract: Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thy- roxine (fT4) based on data collected from a disease- free sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplementation en Vitamines et Mineraux Antioxy- dants (SU.VI.MAX) study had measurements for TSH, fT4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35-60 years and 1025 males aged 45-60 years) with normal thyroid imaging, no previously reported thy- roid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT4 was estimated in males and females. Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29-5.21 mU/L) for ages 35-44 years and 1.98 mU/L (0.27-6.94 mU/L) for ages 45-60 years (p-0.0001, for age). The median (central 95% range) for males

Estimation d’un risque transfusionnel émergent : l’exemple du VHE

Abstract: Resume Objectif L’evaluation du risque transfusionnel est une etape indispensable qui doit preceder toute strategie de depistage d’un agent pathogene transmissible par transfusion. Suite a la survenue de plusieurs cas de transmission par transfusion du VHE en France, une evaluation de risque pour ce virus a ete realisee. Methode Nous avons utilise une methode basee sur la prevalence de l’ARN-VHE sur les dons de plasma servant a la preparation du plasma PFC-SD. Pour estimer cette prevalence sur l’ensemble des dons, les donnees ont ete redressees sur les facteurs de risque du VHE (sexe, âge et region de residence) en faisant l’hypothese qu’ils etaient identiques chez les donneurs de plasma et de sang total. Resultats Parmi les 57 101 dons de plasma testes en 2013, 24 etaient ARN-VHE positifs (taux brut de 4,2 pour 10 000 dons). Apres redressement, le nombre total de dons de sang ARN-VHE positifs a ete estime a 788, soit un taux de 2,65 pour 10 000 dons (IC 95 % : 1,6–3,7) ou 1/3800 dons (1/6200–1/2700). Ce taux est 12 fois plus eleve chez les hommes que chez les femmes, augmente avec l’âge et varie selon la region. Conclusion Le risque de contamination d’un don de sang par le VHE a ete estime a 1 pour 3800 dons en 2013. Une donnee essentielle est toujours manquante pour evaluer maintenant ce risque chez les receveurs : la dose minimale infectieuse. De plus, ce risque-receveur devra etre evalue selon les caracteristiques des patients transfuses : presence d’une immunite anti-VHE, existence d’une hepatopathie chronique ou d’une immunodeficience.

Inadequate Labeling of Pork Sausages Prepared in Corsica Causing a Trichinellosis Outbreak in France

Abstract: Three cases of human trichinellosis due to Trichinella britovi were reported in 2015 in the Southeast of France resulting from consumption of raw pork sausages (figatelli ) prepared in Corsica. Fourteen other people ate figatelli from the same batch but were not infected due to the figatelli being well cooked. This is the first reported human trichinellosis outbreak due to consumption of Corsican sausages prepared from uncontrolled pork. Consumption of raw figatelli is a common tradition in Corsica. As a result, the health recommendation to cook the product well is not always applied. In the present case, the figatelli product label was not sufficiently visible to advise consumers of the risks associated with uncooked pork.

Risque de survenue d’une intoxication par le plomb lors du suivi d’enfants à risque dont la plombémie de primodépistage est inférieure à 100 μg/L

Abstract: Background Follow-up is recommended for children initially screened with a lead blood level below the threshold for lead poisoning of 10 μg/dL when they have one or more risk factors. At first, the frequency of a follow-up lead blood test was calculated in children at risk for lead poisoning. In second time, we calculated the rate of occurrence and independent factors for lead poisoning in the follow-up group. Methods Since 1992, the Greater Paris lead poisoning monitoring system (SSSIILF) has been systematically recording data on lead levels in blood tests conducted for screening and follow-up in Greater Paris. Children initially screened before the age of seven whose blood lead level was inferior to 10 μg/dL and who had one or more risk factors were selected. The association between qualitative variables and a follow-up lead blood test was compared using the Chi 2 test. For children given follow-up, the association between qualitative variables and occurrence of lead poisoning was compared using the Chi 2 test; independent factors for lead poisoning were estimated by logistic regression. Results A follow-up lead blood test was more frequent and the difference was statistically significant, for children with one or more of the following risk factors identified at the time of screening: home address in Seine Saint-Denis or central Paris, screened in mother/child healthcare centers (PMI) or through a private physician, a blood lead level 5 μg/dL on initial screening, young age ( p p p p p Conclusion It is essential to follow up children at risk with an initial lead blood level below 10 μg/dL, especially those initially screened before the age of 24 months. Local action on home environment could also be needed when the initial blood lead level is 5 μg/dL and more than one risk factor has been identified.