Institut de veille sanitaire

About: Institut de veille sanitaire is a healthcare organization based out in Saint-Maurice, France. It is known for research contribution in the topics: Population & Public health. The organization has 1055 authors who have published 1547 publications receiving 56945 citations. The organization is also known as: INVS & InVS.

Surveillance of human Campylobacter infections in France--part 2--implementation of national surveillance.

Abstract: In 2001, one year after the study of microbiological laboratories that showed the feasibility of a surveillance of Campylobacter infections, 1389 private laboratories were asked whether they would be willing to participate. The high proportion of positive responses (48%, 661) allowed the implementation on 1 April 2002 of surveillance of human Campylobacter infections.

Male gonadal dose of ionizing radiation delivered during X-ray examinations and monthly probability of pregnancy: a population-based retrospective study.

Abstract: Male gonadal exposure to ionizing radiation may disrupt spermatogenesis, but its influence on the fecundity of couples has been rarely studied. We aimed to characterize the influence of male gonadal dose of ionizing radiation delivered during radiodiagnostic on the monthly probability of pregnancy. We recruited a random sample of women who retrospectively described 1110 periods of unprotected intercourse beginning between 1985 and 1999 and leading either to a live birth or to no pregnancy; their duration was censored after 13 months. The male partner answered a telephone questionnaire on radiodiagnostic examinations. We assigned a mean gonadal dose to each type of radiodiagnostic examination. We defined male dose for each period of unprotected intercourse as the sum of the gonadal doses of the X-ray examinations experienced between 18 years of age and the date of discontinuation of contraception. Time to pregnancy was analysed using a discrete Cox model with random effect allowing to estimate hazard ratios of pregnancy. After adjustment for female factors likely to influence fecundity, there was no evidence of an association between male dose and the probability of pregnancy (test of homogeneity, p = 0.55). When compared to couples with a male gonadal dose between 0.01 and 0.20 milligrays (n = 321 periods of unprotected intercourse), couples with a gonadal dose above 10 milligrays had a hazard ratio of pregnancy of 1.44 (95% confidence interval, 0.73–2.86, n = 31). Our study provides no evidence of a long-term detrimental effect of male gonadal dose of ionizing radiation delivered during radiodiagnostic on the monthly probability of pregnancy during the year following discontinuation of contraceptive use. Classification errors due to the retrospective assessment of male gonadal exposure may have limited the statistical power of our study.

Connaissance et perception du risque dû au radon en France

Abstract: Resume Objectif de l’etude L’exposition au radon constitue un risque majeur en sante environnementale, restant mal connu de la population generale. Il s’agit notamment de la seconde cause de cancer du poumon apres le tabagisme. L’objectif de cette enquete transversale retrospective etait de dresser un etat des lieux de la connaissance du radon en tant que tel et en tant que facteur de risque, et d’etudier les differents facteurs sociaux qui y sont associes. Materiel et methodes Le Barometre cancer 2010 a interroge la population francaise. Il s’agissait d’une enquete realisee du 3 avril 2010 au 7 aout 2010 par collecte assistee par telephone et informatique, reposant sur un echantillonnage aleatoire a deux degres de 3359 individus âges de 15 a 75 ans. Resultats Le radon restait encore largement meconnu du grand public, y compris dans les departements identifies comme concernes par ce risque. Parmi les personnes âgees de 15 a 75 ans, seule une sur cinq savait que le radon est un gaz naturel provenant du sol. Cette connaissance s’est averee plus frequente parmi les personnes residant dans un departement concerne par le risque du au radon, parmi les hommes et progresse avec l’âge, le niveau de diplome et le niveau de revenu. Lorsque les personnes se trouvaient confrontees a l’exposition au radon, peu envisageaient d’y remedier par des travaux. Conclusion La reussite d’actions de prevention implique l’adhesion et la collaboration des differents acteurs nationaux et locaux intervenant sur ce sujet. Afin d’ameliorer leur impact pour la prevention des cancers du poumon, il pourrait etre plus efficace de coupler ces actions avec des messages de prevention sur le tabac.

An extensive epidemiological investigation of a kidney cancer cluster in a chemical plant: what have we learned?

Abstract: Objectives In 2003, a cluster of renal cell carcinoma (RCC) cases was reported among men working at a French chemical plant using a proprietary process to produce vitamin A. The 10 index cases yielded a standardised incidence ratio of 13.1 for 1994–2002. Nine of these 10 cases were diagnosed by a plant-specific abdominal ultrasonography screening programme that targeted exposure to an intermediate chemical, 4-chloro-1,1-dimethoxy-3-methyl-2-butene, commonly named ‘chloracetal C5’, suspected as the cause by some experts. Epidemiological investigations sought to examine the relations between occupational exposures and RCC. Methods A retrospective cohort mortality study and a nested case–control study were conducted. The cohort study included all workers who had been employed at the plant for at least 6 months between 1960 and 2003. The case–control study included an extensive search within the region for other kidney cancer cases among the cohort members. Industrial hygienists assessed occupational exposure. Results From 1968 to 2006, no significant excess mortality was observed for all causes of death or for all cancers. We found excess mortality for kidney cancer only among women. The nested case–control study showed a dose–response relation for cumulative exposure to chloracetal C5: the OR rose from 2.5 in the low-exposure category to 10.5 in the high-exposure group. Adjustment for screening attenuated this relation. Conclusions The results of the case–control study were consistent with the positive results of in vivo genotoxic tests and suggest that chloracetal C5 can have a causal role in RCC.