Institution
Institut de veille sanitaire
Healthcare•Saint-Maurice, France•
About: Institut de veille sanitaire is a healthcare organization based out in Saint-Maurice, France. It is known for research contribution in the topics: Population & Public health. The organization has 1055 authors who have published 1547 publications receiving 56945 citations. The organization is also known as: INVS & InVS.
Papers published on a yearly basis
Papers
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TL;DR: Interestingly, genes that PRDM5 activates, as opposed to those it represses, are also targets of Gfi1, suggesting a competitive mechanism through which two repressors could cooperate in order to become transcriptional activators.
Abstract: Gfi1 transcriptionally governs hematopoiesis, and its mutations produce neutropenia. In an effort to identify Gfi1-interacting proteins and also to generate new candidate genes causing neutropenia, we performed a yeast two-hybrid screen with Gfi1. Among other Gfi1-interacting proteins, we identified a previously uncharacterized member of the PR domain-containing family of tumor suppressors, PRDM5. PRDM5 has 16 zinc fingers, and we show that it acts as a sequence-specific, DNA binding transcription factor that targets hematopoiesis-associated protein-coding and microRNA genes, including many that are also targets of Gfi1. PRDM5 epigenetically regulates transcription similarly to Gfi1: it recruits the histone methyltransferase G9a and class I histone deacetylases to its target gene promoters and demonstrates repressor activity on synthetic reporters; on endogenous target genes, however, it functions as an activator, in addition to a repressor. Interestingly, genes that PRDM5 activates, as opposed to those it represses, are also targets of Gfi1, suggesting a competitive mechanism through which two repressors could cooperate in order to become transcriptional activators. In neutropenic patients, we identified PRDM5 protein sequence variants perturbing transcriptional function, suggesting a potentially important role in hematopoiesis.
87 citations
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TL;DR: A recent trend towards saturation of the effects of medical practices in post-1945 cohorts associated with an effect of the gradual dissemination of the recommendations relative to the management of thyroid nodules is suggested.
86 citations
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TL;DR: This large population-based study confirms the severe prognosis of heart failure and the need to promote the use of effective medications and management designed to improve survival.
86 citations
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TL;DR: France has been experiencing a measles outbreak with almost 5,000 notified cases as of 30 June 2010, including three measles-related deaths, which underlines the need for additional measures targeting susceptible children and young adults.
Abstract: Since early 2008, France has been experiencing a measles outbreak with almost 5,000 notified cases as of 30 June 2010, including three measles-related deaths. The proportion of cases 20 years or older reached 38% during the first half of 2010. This situation is the consequence of insufficient vaccine coverage (90% at age 24 months in 2007) that led to the accumulation of susceptibles over the last years. It underlines the need for additional measures targeting susceptible children and young adults.
86 citations
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TL;DR: In May 2010, a nationwide excess of infections with the specific monophasic variant Salmonella enterica serotype 4,12:i:- was investigated in France and identified a dried pork sausage sold by a particular chain of supermarkets as the likely vehicle of transmission.
Abstract: In May 2010, a nationwide excess of infections with the specific monophasic variant Salmonella enterica serotype 4,12:i:- was investigated in France. Subtyping with multilocus variable number of tandem repeats analysis revealed a distinct epidemic strain within this excess. Epidemiological investigations identified a dried pork sausage sold by a particular chain of supermarkets as the likely vehicle of transmission. The suspected batches have been withdrawn and recalled.
85 citations
Authors
Showing all 1055 results
Name | H-index | Papers | Citations |
---|---|---|---|
Serge Hercberg | 106 | 942 | 56791 |
Pilar Galan | 97 | 628 | 46782 |
Marcel Goldberg | 70 | 494 | 18659 |
Alexis Elbaz | 69 | 205 | 27260 |
Yannick Béjot | 57 | 331 | 33027 |
Emmanuelle Kesse-Guyot | 57 | 338 | 10914 |
Danielle Seilhean | 54 | 158 | 9153 |
Craig W. Hedberg | 49 | 149 | 12442 |
Jean-Claude Desenclos | 48 | 194 | 7230 |
Katia Castetbon | 46 | 236 | 12396 |
Sandrine Péneau | 44 | 158 | 5507 |
Francis Barin | 43 | 223 | 6235 |
Daniel Lévy-Bruhl | 43 | 221 | 6323 |
Véronique Vaillant | 41 | 117 | 4884 |
Pascal Guénel | 39 | 83 | 5055 |