Institut de veille sanitaire

About: Institut de veille sanitaire is a healthcare organization based out in Saint-Maurice, France. It is known for research contribution in the topics: Population & Public health. The organization has 1055 authors who have published 1547 publications receiving 56945 citations. The organization is also known as: INVS & InVS.

Focus on an unusual rise in pancreatic cancer incidence in France.

Abstract: Background: Pancreatic cancer is one of the most lethal. Most countries have exhibited a stable or decreasing incidence over time. The aim of this study was to provide updated French temporal trends in pancreatic cancer incidence and mortality over the past three decades. Methods: Incidence was estimated using the French National Network of Cancer Registries (FRANCIM) and mortality using the French Mortality Statistics Office. World age-standardized incidence and mortality were modelled by age-period-cohort models. The net cumulative risk of developing pancreatic cancer by birth cohort was calculated, as were annual percentage changes (APCs) in incidence and mortality. Results: Between 1982 and 2012, age-standardized incidence increased from 4.8 in 1980 to 9.6 per 100 000 in men and from 2.3 to 6.8 in women. The mean APC was 2.3% (2.1–2.6) and 3.6% (3.3–3.9), respectively. The cumulative risk of developing pancreatic cancer before age 75 rose from 0.62% for males born around 1920 to 1.17% for those born around 1950. It was respectively 0.31% and 0.86% for women. Mortality did not vary in men (8.1 per 100 000). It slightly increased in women from 4.0 in 1982 to 5.4 in 2012. Conclusion: Pancreatic cancer incidence and mortality exhibited diverging trends. Incidence increased over the last 30 years in France whereas mortality did not vary in men and moderately increased in women. Incidence remained lower than mortality up to 2002. One cannot exclude the possibility that a similar trend may appear in other countries. Etiological studies are required to further explain this increase.

Exploring the determinants of treatment success for tuberculosis cases in Europe.

Abstract: CONTEXTE : Cas regroupes de tuberculose (TB) declares dans 13 pays europeens. OBJECTIF : Analyse des determinants d'un resultat favorable du traitement de la TB dans differents pays, a partir des donneesindividuelles. METHODE : Nous avons demande a 18 pays europeens qui disposent a la fois de donnees sur les resultats des traitements et des donnees individuelles sur les cas de TB de fournir les resultats des cas declares en 2000 et/ou en 2001. Les cas ayant complete leur traitement, avec ou sans confirmation bacteriologique de la guerison, ont ete consideres comme des succes. RESULTATS: Dix pays de l'Union Europeenne, ainsi que l'Islande, la Norvege et la Roumanie, ont participe (72% de reponses). Parmi les 24.660 cas de TB, a l'exception de la Roumanie, nous avons observe 69% de resultats de traitement favorables (60% a 88% selon les pays), 9% de deces (0-11%), 1% d'echecs (0-5%), 4% de perdus de vue ou transferes (2-15%) et 12% (0-23%) de cas sans information. Une regression logistique concernant les cas ayant des resultats d'antibiogramme (n = 10.303) a montre que le succes etait associe au jeune âge (reference : >74 ans; 55-74 ans: OR = 2,0; IC95% 1,8-2,4; 35-54 ans: 3,0; IC95% 2,6-3,5; 15-34 ans: 3,7; IC95% 3,2-4,4; <15 ans: 4,4; IC95% 2,9-6,7), au fait d'etre une femme (1,4; IC95% 1,3-1,6) et a l'absence de polyresistance (9,2; IC95% 6,8-12,4). La proportion de succes (reference: pourcentage de succes le plus bas, en Estonie), etait la plus elevee aux Pays-Bas (1,6; IC95% 1,3-2,0) et en Slovaquie (1,8; IC95% 1,4-2,2), l'Autriche se situant a un niveau plus bas (0,64; IC95% 0,52-0,78). CONCLUSION: La prevention de la resistance aux anti-tuberculeux, l'amelioration de l'adherence des patients a leur traitement et des soins aux personnes âgees, devraient etre prioritaires. La variation de proportion de succes entre pays suggere des differences de completude des donnees de surveillance et d'efficacite des programmes nationaux de lutte contre la TB.

Semen quality trends in French regions are consistent with a global change in environmental exposure

Abstract: A retrospective study carried out recently in a large sample of men, close to the general population, has reported a significant and strong decline in sperm concentration and morphology in the whole of France between 1989 and 2005. We studied these trends within each region of France. Data were obtained from the Fivnat database. The study sample comprised male partners of sterile women in whom both tubes were absent or blocked. They were located at the assisted reproductive technology center. A Bayesian spatio-temporal model with parametric time trends, adjusted for age, was used to model overall time trends for each region. The results show that sperm concentration decreased in almost all regions of France. Among them, Aquitaine showed the highest decrease and Midi-Pyrenees had the lowest average for the whole period. Regarding total motility, most regions showed a slight increase while Bourgogne showed a steep and significant decrease. While considering sperm morphology, there was a decrease in most of the regions. The decrease in Aquitaine and Midi-Pyrenees was stronger when compared with the overall trend. In conclusion, a decrease in sperm concentration and morphology, already shown at the French metropolitan territory level, was observed in most regions of France. This is consistent with a global change in environmental exposure, according to the endocrine disruptor hypothesis especially. Indeed, ubiquitary exposure to chemicals has been growing in the general population of France since the 1950s, and the results do not appear to support the lifestyle hypothesis. The highest decreases and lowest values are consistently observed in two proximate regions that are both highly agricultural and densely populated.

Factors influencing performance of internet-based biosurveillance systems used in epidemic intelligence for early detection of infectious diseases outbreaks.

Abstract: Background Internet-based biosurveillance systems have been developed to detect health threats using information available on the Internet, but system performance has not been assessed relative to end-user needs and perspectives. Method and Findings Infectious disease events from the French Institute for Public Health Surveillance (InVS) weekly international epidemiological bulletin published in 2010 were used to construct the gold-standard official dataset. Data from six biosurveillance systems were used to detect raw signals (infectious disease events from informal Internet sources): Argus, BioCaster, GPHIN, HealthMap, MedISys and ProMED-mail. Crude detection rates (C-DR), crude sensitivity rates (C-Se) and intrinsic sensitivity rates (I-Se) were calculated from multivariable regressions to evaluate the systems’ performance (events detected compared to the gold-standard) 472 raw signals (Internet disease reports) related to the 86 events included in the gold-standard data set were retrieved from the six systems. 84 events were detected before their publication in the gold-standard. The type of sources utilised by the systems varied significantly (p<0001). I-Se varied significantly from 43% to 71% (p = 0001) whereas other indicators were similar (C-DR: p = 020; C-Se, p = 013). I-Se was significantly associated with individual systems, types of system, languages, regions of occurrence, and types of infectious disease. Conversely, no statistical difference of C-DR was observed after adjustment for other variables. Conclusion Although differences could result from a biosurveillance system's conceptual design, findings suggest that the combined expertise amongst systems enhances early detection performance for detection of infectious diseases. While all systems showed similar early detection performance, systems including human moderation were found to have a 53% higher I-Se (p = 00001) after adjustment for other variables. Overall, the use of moderation, sources, languages, regions of occurrence, and types of cases were found to influence system performance.