Institution
Institut de veille sanitaire
Healthcare•Saint-Maurice, France•
About: Institut de veille sanitaire is a healthcare organization based out in Saint-Maurice, France. It is known for research contribution in the topics: Population & Public health. The organization has 1055 authors who have published 1547 publications receiving 56945 citations. The organization is also known as: INVS & InVS.
Papers published on a yearly basis
Papers
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TL;DR: The ready-to-wear approach is reliable if epidemic and vaccine strains are genetically close and other meningococcal B clonal outbreaks might benefit from this strategy; and previously described outer-membrane-vesicle vaccines can be effective against various strains.
Abstract: Summary Background Outer-membrane-vesicle vaccines for meningococcal B outbreaks are complex and time consuming to develop. We studied the use of already available vaccine to control an outbreak caused by a genetically close strain. Methods From 2006 to 2009, all individuals younger than 20 years living in the region of Normandy, France, in which an outbreak caused by a B:14:P1.7,16 strain occurred, were eligible to receive MenBvac, a Norwegian vaccine designed 20 years earlier against a strain sharing the same serosubtype (B:15:P1.7,16). The immunogenicity (in a randomly selected cohort of 400 children aged 1–5 years), safety, and epidemiological effect of the vaccination were assessed. Findings 26 014 individuals were eligible to receive the vaccine. Shortage of vaccine production prompted start of the campaign in the highest incidence groups (1–5 years). 16 709 (64%) received a complete vaccination schedule of whom 13 589 (81%) received a 2+1 dose schedule (week 0, week 6, and month 8). At 6 weeks after the third dose, of 235 vaccinees for whom samples were available, 206 (88%) had a seroresponse, and 108 (56 %) of 193 had a seroresponse at 15 months. These results were similar to those described for tailor-made vaccines and their homologous strain. Only previously described adverse effects occurred. The incidence of B:14:P1.7,16 cases decreased significantly in the vaccine targeted population after the primary vaccination period (from 31·6 per 100 000 to 5·9 per 100 000; p=0·001). Interpretation The ready-to-wear approach is reliable if epidemic and vaccine strains are genetically close. Other meningococcal B clonal outbreaks might benefit from this strategy; and previously described outer-membrane-vesicle vaccines can be effective against various strains. Funding French Ministry of Health.
101 citations
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TL;DR: While no data suggested that the municipal water supply was contaminated, safe water systems and hand hygiene practices might have prevented a high proportion of cases if implemented early during this outbreak.
Abstract: The aim of this study was to identify the risk factors for cholera during an outbreak in Nigeria. Cases were defined as recent onset of acute diarrhoea with dehydration in a patient hospitalised at the Infectious Diseases Hospital in Kano City. Meningitis patients admitted concurrently at the same hospital were recruited as unmatched controls. Data were collected on age, sex, place of residence, hygienic practices, and on food and water consumption. A total of 5600 cholera cases and 340 cholera deaths were reported between December 1995 and May 1996 (attack rate=86.3 per 100,000 population) in the state of Kano. Compared to the 77 controls, the 102 cases were more likely to have drunk street-vended water (age-adjusted odds ratio (AAOR)=3.2; 95% confidence interval (CI): 1.4–7.1) and less likely to have drunk tap water in their homes (AAOR=0.2; 95% CI: 0.1–0.7) or to have washed hands with soap prior to eating food (AAOR=0.2; 95% CI: 0.1–0.6). While no data suggested that the municipal water supply was contaminated, safe water systems and hand hygiene practices might have prevented a high proportion of cases if implemented early during this outbreak.
101 citations
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TL;DR: Multivariate analysis showed that the risk of M xenopi spinal infection was related to nucleotomy and high number of patients per operating session, and patients who have been exposed to an iatrogenic infectious hazard should be screened promptly and receive effective information.
100 citations
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TL;DR: The incidence of all ADCs continued to fall, including cervical cancer, in the cART period, but the risk remained higher than in the general population in 2005-2009, but in patients with stably restored immunity, KS remained significantly more frequent than inThe general population.
Abstract: We examined trends in the incidence of the 3 AIDS-defining cancers (ADCs; Kaposi sarcoma [KS], non-Hodgkin lymphoma [NHL], and cervical cancer) among human immunodeficiency virus (HIV)-infected patients relative to the general population between 1992 and 2009 in France, focusing on age at ADC diagnosis and on patients with controlled viral load and restored immunity on combination antiretroviral therapy (cART). Age- and sex-standardized incidence rates were estimated in patients enrolled in the French hospital database on HIV, and in the general population in France during 4 calendar periods (1992-1996, 1997-2000, 2001-2004, and 2005-2009). Standardized incidence ratios (SIRs) were calculated for all periods and separately for patients on cART, with CD4 counts ≥500 cells/µL for at least 2 years and viral load ≤500 copies/mL. Although the incidence of ADCs fell significantly across the calendar periods, the risk remained constantly higher in HIV-infected patients than in the general population. In patients with restored immunity, the relative risk remained significantly elevated for KS (SIR = 35.4; 95% confidence interval [CI], 18.3-61.9), and was similar to that of the general population for NHL (SIR = 1.0; 95% CI, .4-1.8). ADCs were diagnosed at a younger age in HIV-infected patients, with a particularly marked difference for NHL (-11.3 years, P < .0001). The incidence of all ADCs continued to fall, including cervical cancer, in the cART period, but the risk remained higher than in the general population in 2005-2009. In patients with stably restored immunity, KS remained significantly more frequent than in the general population.
100 citations
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TL;DR: An outbreak of gastrointestinal illness in students who ate in a secondary school canteen in the administrative departement of Haute-Loire, central France was reported to the local health authorities on 23 March 2005.
Abstract: An outbreak of gastrointestinal illness in students who ate in a secondary school canteen in the administrative departement of Haute-Loire, central France was reported to the local health authorities on 23 March 2005
99 citations
Authors
Showing all 1055 results
Name | H-index | Papers | Citations |
---|---|---|---|
Serge Hercberg | 106 | 942 | 56791 |
Pilar Galan | 97 | 628 | 46782 |
Marcel Goldberg | 70 | 494 | 18659 |
Alexis Elbaz | 69 | 205 | 27260 |
Yannick Béjot | 57 | 331 | 33027 |
Emmanuelle Kesse-Guyot | 57 | 338 | 10914 |
Danielle Seilhean | 54 | 158 | 9153 |
Craig W. Hedberg | 49 | 149 | 12442 |
Jean-Claude Desenclos | 48 | 194 | 7230 |
Katia Castetbon | 46 | 236 | 12396 |
Sandrine Péneau | 44 | 158 | 5507 |
Francis Barin | 43 | 223 | 6235 |
Daniel Lévy-Bruhl | 43 | 221 | 6323 |
Véronique Vaillant | 41 | 117 | 4884 |
Pascal Guénel | 39 | 83 | 5055 |