Institution
Kagawa University
Education•Takamatsu, Japan•
About: Kagawa University is a education organization based out in Takamatsu, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 6028 authors who have published 11918 publications receiving 224111 citations. The organization is also known as: Kagawa Daigaku.
Topics: Cancer, Population, Angiotensin II, Gene, Lung cancer
Papers published on a yearly basis
Papers
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TL;DR: The findings confirm previous observations that low-frequency, low-intensity rTMS to motor cortex can produce transient depression of MEP excitability and reduces the excitability of cortical neurones in relaxed subjects, so that responses to a given input are smaller than before conditioning.
334 citations
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TL;DR: This work shows a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood, and indicates that the hormone is critically involved in improving hippocampus-dependent learning and memory in mice.
Abstract: Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylation of cyclic AMP-responsive element binding protein (CREB), and MAP kinase inhibitors blocked these inductions. An increase in CREB phosphorylation and L-LTP induced by one-train tetanus were observed in the multiparous mouse hippocampus without oxytocin application. Furthermore, intracerebroventricular injection of oxytocin in virgin mice improved long-term spatial learning in vivo, whereas an injection of oxytocin antagonist in multiparous mice significantly inhibited the improved spatial memory, L-LTP and CREB phosphorylation. These findings indicate that oxytocin is critically involved in improving hippocampus-dependent learning and memory during motherhood in mice.
333 citations
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TL;DR: It is suggested that both betaine and proline provide a protective action against Cd-induced oxidative stress by reducing H2O2 and lipid peroxidation levels and by increasing the antioxidant defense and MG detoxification systems.
Abstract: The present study investigates the possible mediatory role of exogenously applied glycinebetaine (betaine) and proline on reactive oxygen species (ROS) and methylglyoxal (MG) detoxification systems in mung bean seedlings subjected to cadmium (Cd) stress (1 mM CdCl2, 48 h). Cadmium stress caused a significant increase in glutathione (GSH) and glutathione disulfide (GSSG) content, while the ascorbate (AsA) content decreased significantly with a sharp increase in hydrogen peroxide (H2O2) and lipid peroxidation level (MDA). Ascorbate peroxidase (APX), glutathione S-transferase (GST), glutathione peroxidase (GPX), and glyoxalase I (Gly I) activities were increased in response to Cd stress, while the activities of catalase (CAT), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR) and glyoxalase II (Gly II) were sharply decreased. Exogenous application of 5 mM betaine or 5 mM proline resulted in an increase in GSH and AsA content, maintenance of a high GSH/GSSG ratio and increased the activities of APX, DHAR, MDHAR, GR, GST, GPX, CAT, Gly I and Gly II involved in ROS and MG detoxification system as compared to the control and mostly also Cd-stressed plants, with a concomitant decrease in GSSG content, H2O2 and lipid peroxidation level. These findings together with our earlier findings suggest that both betaine and proline provide a protective action against Cd-induced oxidative stress by reducing H2O2 and lipid peroxidation levels and by increasing the antioxidant defense and MG detoxification systems.
329 citations
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TL;DR: Results indicate that intestinal function was activated by the depressed blood ammonia concentration in the body of the chicken, and may suggest that the B. subtilis natto has the potential to be a beneficial microorganism in chickens.
Abstract: Two experiments were conducted. In experiment 1, chickens were fed dried Bacillus subtilis var. natto for 3 or 28 days. Growth performance and internal organs were not different from controls, but feed efficiency tended to be improved in the 28-day feeding. In these birds, blood ammonia concentration was decreased (P<0.05). Blood glucose concentration, and amylase and lipase activity in the intestinal content were not significantly different among dietary groups. These results suggest that the B. subtilis natto depressed ammonia concentration. In experiment 2, chickens were fed dietary B. subtilis natto for 28 days. These birds had a tendency to display greater growth performance and intestinal histologies, such as villus height, cell area and cell mitosis, than the controls. Flat cell outline on the duodenal villus surface in controls developed large, protruded cell clusters and cell protuberances after feeding of dietary B. subtilis natto. These results indicate that intestinal function was activated by the depressed blood ammonia concentration in the body of the chicken. The present results may suggest that the B. subtilis natto has the potential to be a beneficial microorganism in chickens.
328 citations
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328 citations
Authors
Showing all 6051 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yuji Matsuzawa | 143 | 836 | 116711 |
Masatsugu Hori | 113 | 874 | 48028 |
Stewart T. Cole | 109 | 511 | 51942 |
Jian Feng Ma | 97 | 305 | 32310 |
H. Phillip Koeffler | 92 | 479 | 29428 |
Naoto Chatani | 87 | 597 | 26370 |
Takenobu Kamada | 86 | 700 | 27535 |
Juhn G. Liou | 83 | 301 | 21042 |
Hirofumi Makino | 82 | 803 | 30523 |
Jonathan W. Said | 78 | 437 | 25399 |
Junhua Li | 77 | 480 | 21626 |
Akira Nishiyama | 75 | 619 | 22487 |
Masayuki Fujita | 70 | 740 | 17847 |
Jun Hirabayashi | 66 | 270 | 15579 |
Mark R. Wormald | 64 | 179 | 14686 |