Institution
National Health and Family Planning Commission
Government•Beijing, China•
About: National Health and Family Planning Commission is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Kashin–Beck disease. The organization has 2379 authors who have published 1440 publications receiving 20078 citations. The organization is also known as: Ministry of Health of the People's Republic of China.
Topics: Population, Kashin–Beck disease, Medicine, Pregnancy, Health care
Papers
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TL;DR: The observed diversity in the P. ovale curtisi surface antigens supports consideration that the two parasites be given species status, and a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family are described.
61 citations
Sun Yat-sen University1, University of Washington2, National Cheng Kung University3, Shanghai Jiao Tong University4, Fred Hutchinson Cancer Research Center5, Centers for Disease Control and Prevention6, Guangzhou Medical University7, National Health and Family Planning Commission8, South Korean Ministry for Health, Welfare and Family Affairs9, University of New South Wales10
TL;DR: Evidence that circumcision is likely to protect MSM from HIV infection, particularly in countries of low and middle income is found, and MSM should be included in campaigns promoting circumcision among men in countriesof low andmiddle income.
61 citations
TL;DR: DEHP-caused oxidative stress and Mdm2 downregulation contribute to p53 activation, and the p53-dependent apoptotic pathway plays critical and indispensable roles in DEHP-induced hepatotoxicity, while the Fas/FasL pathway does not involve in this molecular event.
61 citations
TL;DR: It is shown that Wnt activation followed by Notch inhibition strongly promotes the mitotic regeneration of new HCs in both normal and neomycin-damaged cochleae while partially preserving the SC number.
Abstract: Hair cell (HC) loss is the main cause of permanent hearing loss in mammals. Previous studies have reported that in neonatal mice cochleae, Wnt activation promotes supporting cell (SC) proliferation and Notch inhibition promotes the trans-differentiation of SCs into HCs. However, Wnt activation alone fails to regenerate significant amounts of new HCs, Notch inhibition alone regenerates the HCs at the cost of exhausting the SC population, which leads to the death of the newly regenerated HCs. Mitotic HC regeneration might preserve the SC number while regenerating the HCs, which could be a better approach for long-term HC regeneration. We present a two-step gene manipulation, Wnt activation followed by Notch inhibition, to accomplish mitotic regeneration of HCs while partially preserving the SC number. We show that Wnt activation followed by Notch inhibition strongly promotes the mitotic regeneration of new HCs in both normal and neomycin-damaged cochleae while partially preserving the SC number. Lineage tracing shows that the majority of the mitotically regenerated HCs are derived specifically from the Lgr5+ progenitors with or without HC damage. Our findings suggest that the co-regulation of Wnt and Notch signaling might provide a better approach to mitotically regenerate HCs from Lgr5+ progenitor cells.
61 citations
TL;DR: Evidence that exposure to heatwaves during the final gestational week can independently trigger preterm birth is strengthened, which adds new evidence to the current understanding of combined effects of air pollution and meteorological variables on adverse birth outcomes.
Abstract: Background: Both extreme heat and air pollution exposure during pregnancy have been associated with preterm birth; however, their combined effects are unclear. Objectives: Our goal was to estimate ...
61 citations
Authors
Showing all 2403 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Feng Zhang | 172 | 1278 | 181865 |
| Yang Yang | 171 | 2644 | 153049 |
| Lei Zhang | 135 | 2240 | 99365 |
| Jian Zhang | 107 | 3064 | 69715 |
| Wei Wang | 95 | 3544 | 59660 |
| Jie Li | 76 | 843 | 32221 |
| Jing Liu | 73 | 1351 | 27169 |
| Haidong Kan | 71 | 405 | 44210 |
| Wei Wang | 66 | 673 | 20023 |
| Jin-Tai Yu | 66 | 439 | 20020 |
| Qi Jin | 64 | 335 | 45892 |
| Chuan Qin | 60 | 326 | 21708 |
| Ji-Sheng Han | 60 | 339 | 13660 |
| Ying Zhou | 60 | 663 | 14349 |
| Jun Huang | 57 | 445 | 12176 |