Institution
Qingdao University
Education•Qingdao, China•
About: Qingdao University is a education organization based out in Qingdao, China. It is known for research contribution in the topics: Cancer & Apoptosis. The organization has 35675 authors who have published 27275 publications receiving 374908 citations. The organization is also known as: Qīngdǎo Dàxué.
Topics: Cancer, Apoptosis, Cell growth, Medicine, Graphene
Papers published on a yearly basis
Papers
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TL;DR: Li et al. as mentioned in this paper proposed a transplantable LiF-rich layer (TLL) that can suppress the side reactions between electrolyte and lithium metal, which could be used to protect Li metal anodes.
141 citations
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TL;DR: Wang et al. as mentioned in this paper examined the relationship among environmental regulations (ER), staff quality (SQ), R&D efficiency (RDE), green technology (GT), and profit.
141 citations
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TL;DR: A three-stage SSL approach using data augmentation (DA) and metric learning is proposed for an intelligent bearing fault diagnosis under limited labeled data to demonstrate that the proposed method can perform better in bearing fault diagnosed under limited labeling samples than existing diagnostic methods.
141 citations
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Zhejiang University1, University of Texas MD Anderson Cancer Center2, University of Texas Health Science Center at Houston3, Qingdao University4, Chinese Academy of Sciences5, Nanjing Medical University6, Dong-a University7, Wenzhou Medical College8, Second Military Medical University9, Houston Methodist Hospital10, Tsinghua University11, China Medical University (Taiwan)12
TL;DR: Activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90, which highlights the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of HCC.
Abstract: Cancer cells increase lipogenesis for their proliferation and the activation of sterol regulatory element-binding proteins (SREBPs) has a central role in this process. SREBPs are inhibited by a complex composed of INSIG proteins, SREBP cleavage-activating protein (SCAP) and sterols in the endoplasmic reticulum. Regulation of the interaction between INSIG proteins and SCAP by sterol levels is critical for the dissociation of the SCAP–SREBP complex from the endoplasmic reticulum and the activation of SREBPs1,2. However, whether this protein interaction is regulated by a mechanism other than the abundance of sterol—and in particular, whether oncogenic signalling has a role—is unclear. Here we show that activated AKT in human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90. Phosphorylated PCK1 translocates to the endoplasmic reticulum, where it uses GTP as a phosphate donor to phosphorylate INSIG1 at Ser207 and INSIG2 at Ser151. This phosphorylation reduces the binding of sterols to INSIG1 and INSIG2 and disrupts the interaction between INSIG proteins and SCAP, leading to the translocation of the SCAP–SREBP complex to the Golgi apparatus, the activation of SREBP proteins (SREBP1 or SREBP2) and the transcription of downstream lipogenesis-related genes, proliferation of tumour cells, and tumorigenesis in mice. In addition, phosphorylation of PCK1 at Ser90, INSIG1 at Ser207 and INSIG2 at Ser151 is not only positively correlated with the nuclear accumulation of SREBP1 in samples from patients with HCC, but also associated with poor HCC prognosis. Our findings highlight the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of HCC. Phosphorylation of INSIG1 and INSIG2 by PCK1 leads to a reduction in the binding of sterols, the activation of SREBP1 and SREBP2 and the downstream transcription of lipogenesis-associated genes that promote tumour growth.
141 citations
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TL;DR: In this paper, the authors examined the effects of financial instability on consumption-based carbon emission in the presence of international trade, technological innovation, and economic growth in Emerging Seven (E-7) countries from 1995-2018.
140 citations
Authors
Showing all 35843 results
Name | H-index | Papers | Citations |
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Marjo-Riitta Järvelin | 156 | 923 | 100939 |
Seeram Ramakrishna | 147 | 1552 | 99284 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |
Peng Shi | 137 | 1371 | 65195 |
Jie Liu | 131 | 1531 | 68891 |
Jun Yu | 121 | 1174 | 81186 |
Yu-Guo Guo | 113 | 429 | 47383 |
Xiaoming Li | 113 | 1932 | 72445 |
Wei Zhang | 112 | 1189 | 93641 |
Jie Wu | 112 | 1537 | 56708 |
Qian Wang | 108 | 2148 | 65557 |
Yongmei Liu | 100 | 407 | 42382 |
Shuzhi Sam Ge | 97 | 883 | 40865 |
Chang Ming Li | 97 | 896 | 42888 |
Guo-Qiang Chen | 94 | 621 | 45953 |