Queen's University Belfast

About: Queen's University Belfast is a education organization based out in Belfast, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 25457 authors who have published 55463 publications receiving 1751346 citations. The organization is also known as: Queen's College, Belfast & Queen's College.

The death of massive stars – I. Observational constraints on the progenitors of Type II-P supernovae

Abstract: We present the results of a 10.5-yr, volume-limited (28-Mpc) search for supernova (SN) progenitor stars. In doing so we compile all SNe discovered within this volume (132, of which 27 per cent are Type Ia) and determine the relative rates of each subtype from literature studies. The core-collapse SNe break down into 59 per cent II-P and 29 per cent Ib/c, with the remainder being IIb (5 per cent), IIn (4 per cent) and II-L (3 per cent). There have been 20 II-P SNe with high-quality optical or near-infrared pre-explosion images that allow a meaningful search for the progenitor stars. In five cases they are clearly red supergiants, one case is unconstrained, two fall on compact coeval star clusters and the other twelve have no progenitor detected. We review and update all the available data for the host galaxies and SN environments (distance, metallicity and extinction) and determine masses and upper mass estimates for these 20 progenitor stars using the STARS stellar evolutionary code and a single consistent homogeneous method. A maximum likelihood calculation suggests that the minimum stellar mass for a Type II-P to form is mmin= 8.5+1−1.5 M⊙ and the maximum mass for II-P progenitors is mmax= 16.5 ± 1.5 M⊙, assuming a Salpeter initial mass function holds for the progenitor population (in the range Γ=−1.35+0.3−0.7). The minimum mass is consistent with current estimates for the upper limit to white dwarf progenitor masses, but the maximum mass does not appear consistent with massive star populations in Local Group galaxies. Red supergiants in the Local Group have masses up to 25 M⊙ and the minimum mass to produce a Wolf–Rayet star in single star evolution (between solar and LMC metallicity) is similarly 25–30 M⊙. The reason we have not detected any high-mass red supergiant progenitors above 17 M⊙ is unclear, but we estimate that it is statistically significant at 2.4σ confidence. Two simple reasons for this could be that we have systematically underestimated the progenitor masses due to dust extinction or that stars between 17–25 M⊙ produce other kinds of SNe which are not II-P. We discuss these possibilities and find that neither provides a satisfactory solution. We term this discrepancy the ‘red supergiant problem’ and speculate that these stars could have core masses high enough to form black holes and SNe which are too faint to have been detected. We compare the 56Ni masses ejected in the SNe to the progenitor mass estimates and find that low-luminosity SNe with low 56Ni production are most likely to arise from explosions of low-mass progenitors near the mass threshold that can produce a core-collapse.

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Abstract: Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10-6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10-5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

An Observational Overview of Solar Flares

Abstract: We present an overview of solar flares and associated phenomena, drawing upon a wide range of observational data primarily from the RHESSI era Following an introductory discussion and overview of the status of observational capabilities, the article is split into topical sections which deal with different areas of flare phenomena (footpoints and ribbons, coronal sources, relationship to coronal mass ejections) and their interconnections We also discuss flare soft X-ray spectroscopy and the energetics of the process The emphasis is to describe the observations from multiple points of view, while bearing in mind the models that link them to each other and to theory The present theoretical and observational understanding of solar flares is far from complete, so we conclude with a brief discussion of models, and a list of missing but important observations

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

Abstract: Genomic copy number variants (CNVs) have been strongly implicated in the etiology of schizophrenia (SCZ). However, apart from a small number of risk variants, elucidation of the CNV contribution to risk has been difficult due to the rarity of risk alleles, all occurring in less than 1% of cases. We sought to address this obstacle through a collaborative effort in which we applied a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. We observed a global enrichment of CNV burden in cases (OR=1.11, P=5.7e-15), which persisted after excluding loci implicated in previous studies (OR=1.07, P=1.7e-6). CNV burden is also enriched for genes associated with synaptic function (OR = 1.68, P = 2.8e-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P= 7.3e-5). We identified genome-wide significant support for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. We find support at a suggestive level for nine additional candidate susceptibility and protective loci, which consist predominantly of CNVs mediated by non-allelic homologous recombination (NAHR).

Molecular logic and computing.

Abstract: Molecular substrates can be viewed as computational devices that process physical or chemical 'inputs' to generate 'outputs' based on a set of logical operators. By recognizing this conceptual crossover between chemistry and computation, it can be argued that the success of life itself is founded on a much longer-term revolution in information handling when compared with the modern semiconductor computing industry. Many of the simpler logic operations can be identified within chemical reactions and phenomena, as well as being produced in specifically designed systems. Some degree of integration can also be arranged, leading, in some instances, to arithmetic processing. These molecular logic systems can also lend themselves to convenient reconfiguring. Their clearest application area is in the life sciences, where their small size is a distinct advantage over conventional semiconductor counterparts. Molecular logic designs aid chemical (especially intracellular) sensing, small object recognition and intelligent diagnostics.